Literature DB >> 7875330

Unique molecular properties of superoxide dismutase from teleost fish skin.

T Nakano1, M Sato, M Takeuchi.   

Abstract

A unique Cu,Zn-SOD was found and isolated from plaice Paralichthys olivaceus skin. Surprisingly, the properties of purified fish skin SOD were very different from those of SOD from other sources reported so far. The purified SOD was composed of four same subunits of 16 kDa and the molecular weight of the native SOD was found to be around 65 kDa. The dominant amino acids of the SOD were Ser, Thr, Pro and Glu. Above 70 degrees C, thermostability of the SOD was much lower than that of bovine erythrocyte Cu,Zn-SOD.

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Year:  1995        PMID: 7875330     DOI: 10.1016/0014-5793(95)00084-m

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  1 in total

1.  A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening.

Authors:  Marc M J Da Costa; Claire E Allen; Adrian Higginbottom; Tennore Ramesh; Pamela J Shaw; Christopher J McDermott
Journal:  Dis Model Mech       Date:  2013-10-02       Impact factor: 5.758

  1 in total

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