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Literature DB >> 7875253

Expression of multidrug resistance (mdr) gene(s) in primary lymphoid organs of chicken immune system during embryonic development.

M Petrini¹, S Galimberti, A Sabbatini, F Bianchi, N Bernardini, A Dolfi, M Lupetti.

Abstract

The presence of a multidrug resistance (MDR) related protein, P-170, in normal and pathological lymphoid cells has been described. The present report evaluates the expression of the mdr 1 gene by using the reverse Polymerase Chain Reaction (PCR) on cells obtained from the thymus and bursa of chicken embryos starting from day 12 until hatching. Results show that the thymic cells are positive from day 12 to the end of the observation period. In contrast, mdr mRNA was detected in the bursa from day 14 to day 17 of embryonic life. Possible relationships between the expression of mdr and the development of T and B lymphocytes are discussed.

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Year: 1995 PMID： 7875253 DOI： 10.1007/bf01929357

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

26 in total

1. P-glycoprotein epitope mapping. I. Identification of a linear human-specific epitope in the fourth loop of the P-glycoprotein extracellular domain by MM4.17 murine monoclonal antibody to human multi-drug-resistant cells.

Authors: M Cianfriglia; M C Willingham; M Tombesi; G V Scagliotti; G Frasca; A Chersi
Journal: Int J Cancer Date: 1994-01-02 Impact factor: 7.396

2. Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals.

Authors: R K Burt; S Garfield; K Johnson; S S Thorgeirsson
Journal: Carcinogenesis Date: 1988-12 Impact factor: 4.944

3. Development and function of the immunoglobulin producing system. I. Effect of bursectomy at different stages of development on germinal centers, plasma cells, immunoglobulins and antibody production.

Authors: M D Cooper; W A Cain; P J Van Alten; R A Good
Journal: Int Arch Allergy Appl Immunol Date: 1969

4. Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells.

Authors: I B Roninson; H T Abelson; D E Housman; N Howell; A Varshavsky
Journal: Nature Date: 1984 Jun 14-20 Impact factor: 49.962

5. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells.

Authors: P M Chaudhary; I B Roninson
Journal: Cell Date: 1991-07-12 Impact factor: 41.582

6. Expression of the multidrug resistance gene product (P-glycoprotein) in myelodysplasia is associated with a stem cell phenotype.

Authors: A F List; C M Spier; A Cline; D C Doll; H Garewal; R Morgan; A A Sandberg
Journal: Br J Haematol Date: 1991-05 Impact factor: 6.998

Expression of multidrug resistance (mdr) gene(s) in primary lymphoid organs of chicken immune system during embryonic development.

1. P-glycoprotein epitope mapping. I. Identification of a linear human-specific epitope in the fourth loop of the P-glycoprotein extracellular domain by MM4.17 murine monoclonal antibody to human multi-drug-resistant cells.

2. Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals.

3. Development and function of the immunoglobulin producing system. I. Effect of bursectomy at different stages of development on germinal centers, plasma cells, immunoglobulins and antibody production.

4. Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells.

5. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells.

6. Expression of the multidrug resistance gene product (P-glycoprotein) in myelodysplasia is associated with a stem cell phenotype.

7. Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines.

8. Expression of P-glycoprotein and anionic glutathione S-transferase genes in non-Hodgkin's lymphoma.

9. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

10. Ontogeny of B cells in the chicken. I. Sequential development of clonal diversity in the bursa.

1. ATP-binding cassette (ABC) transporter expression and localization in sea urchin development.