Literature DB >> 7875247

The effect of a phorbol ester upon the cholinergic regulation of potassium permeability in the rat submandibular gland.

J D Pediani1, S M Wilson.   

Abstract

Acetylcholine releases calcium from cytoplasmic stores and permits an influx of calcium in salivary acinar cells. The resultant rise in [Ca2+]i causes an increase in potassium permeability which is an important part of the secretory response. We have investigated the effects of 12-O-tetradecanoyl phorbol-13-acetate, a potent activator of protein kinase C, upon this regulation of potassium permeability in superfused pieces of rat submandibular salivary gland. This compound inhibited the initial [Ca2+]O-independent component of the response of acetylcholine but had no effect upon the subsequent [Ca2+]O-dependent phase. This compound does not, therefore, appear to inhibit receptor-regulated calcium influx.

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Year:  1995        PMID： 7875247     DOI： 10.1007/bf01929350

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

Review 1.  Stimulus-secretion coupling: cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells.

Authors:  O H Petersen
Journal:  J Physiol       Date:  1992-03       Impact factor: 5.182

Review 2.  The molecular heterogeneity of protein kinase C and its implications for cellular regulation.

Authors:  Y Nishizuka
Journal:  Nature       Date:  1988-08-25       Impact factor: 49.962

3.  Protein kinase C activators inhibit the inositol trisphosphate-mediated muscarinic current responses in rat lacrimal cells.

Authors:  I Llano; A Marty
Journal:  J Physiol       Date:  1987-12       Impact factor: 5.182

4.  Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.

Authors:  S A Orellana; P A Solski; J H Brown
Journal:  J Biol Chem       Date:  1985-05-10       Impact factor: 5.157

5.  Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells.

Authors:  L M Vicentini; F Di Virgilio; A Ambrosini; T Pozzan; J Meldolesi
Journal:  Biochem Biophys Res Commun       Date:  1985-02-28       Impact factor: 3.575

6.  Potassium (86Rb+) efflux from the rat submandibular gland under sodium-free conditions in vitro.

Authors:  D L Bovell; H Y Elder; J D Pediani; S M Wilson
Journal:  J Physiol       Date:  1989-09       Impact factor: 5.182

7.  EGTA purity and the buffering of calcium ions in physiological solutions.

Authors:  D J Miller; G L Smith
Journal:  Am J Physiol       Date:  1984-01

8.  Biphasic modulation of potassium release in rat parotid gland by carbachol and phenylephrine.

Authors:  J W Putney
Journal:  J Pharmacol Exp Ther       Date:  1976-08       Impact factor: 4.030

9.  Patch-clamp study of rubidium and potassium conductances in single cation channels from mammalian exocrine acini.

Authors:  D V Gallacher; Y Maruyama; O H Petersen
Journal:  Pflugers Arch       Date:  1984-08       Impact factor: 3.657

10.  Extracellular ATP can activate autonomic signal transduction pathways in cultured equine sweat gland epithelial cells.

Authors:  W H Ko; J J O'Dowd; J D Pediani; D L Bovell; H Y Elder; D M Jenkinson; S M Wilson
Journal:  J Exp Biol       Date:  1994-05       Impact factor: 3.312
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  1 in total

Review 1.  Second-hand chloroplasts and the case of the disappearing nucleus.

Authors:  J D Palmer; C F Delwiche
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-23       Impact factor: 11.205
  1 in total

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