Literature DB >> 7874751

Sequence analysis of three deficient mutants of cytochrome oxidase subunit I of Saccharomyces cerevisiae and their revertants.

P Lemarre1, S Robineau, A M Colson, P Netter.   

Abstract

Three respiratory-deficient mutants of cytochrome oxidase subunit I in the yeast mitochondrion have been sequenced. They are located in, or near, transmembrane segment VI, the catalytic core of the enzyme. Respiratory-competent revertants have been selected and studied. The mutant V244M was found to revert at the same site in valine (wild-type), isoleucine or threonine. The revertants of the mutant G251R were of three types: glycine (wild-type), serine and threonine at position 251. A search for second-site mutations was carried out but none were found. Among 60 revertants tested, the mutant K265M was found to revert only to the wild-type allele.

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Year:  1994        PMID： 7874751     DOI： 10.1007/bf00309948

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  25 in total

1.  Improved cloning efficiency of polymerase chain reaction (PCR) products after proteinase K digestion.

Authors:  J S Crowe; H J Cooper; M A Smith; M J Sims; D Parker; D Gewert
Journal:  Nucleic Acids Res       Date:  1991-01-11       Impact factor: 16.971

Review 2.  Evolutionary aspects of cytochrome c oxidase.

Authors:  B Kadenbach; A Stroh; F J Hüther; A Reimann; D Steverding
Journal:  J Bioenerg Biomembr       Date:  1991-04       Impact factor: 2.945

Review 3.  Binuclear centre structure of terminal protonmotive oxidases.

Authors:  S Brown; A J Moody; R Mitchell; P R Rich
Journal:  FEBS Lett       Date:  1993-02-01       Impact factor: 4.124

Review 4.  Cytochrome c oxidase: structure, function, and membrane topology of the polypeptide subunits.

Authors:  C E Cooper; P Nicholls; J A Freedman
Journal:  Biochem Cell Biol       Date:  1991-09       Impact factor: 3.626

5.  Slow ('resting') forms of mitochondrial cytochrome c oxidase consist of two kinetically distinct conformations of the binuclear CuB/a3 centre--relevance to the mechanism of proton translocation.

Authors:  C E Cooper; S Jünemann; N Ioannidis; J M Wrigglesworth
Journal:  Biochim Biophys Acta       Date:  1993-09-13

6.  Substitution of an invariant nucleotide at the base of the highly conserved '530-loop' of 15S rRNA causes suppression of yeast mitochondrial ochre mutations.

Authors:  Z H Shen; T D Fox
Journal:  Nucleic Acids Res       Date:  1989-06-26       Impact factor: 16.971

7.  Cytoduction: a tool for mitochondrial genetic studies in yeast. Utilization of the nuclear-fusion mutation kar 1-1 for transfer of drug r and mit genomes in Saccharomyces cerevisiae.

Authors:  W E Lancashire; J R Mattoon
Journal:  Mol Gen Genet       Date:  1979-03-05

8.  Insight into the interactions between subunits I and II of the cytochrome c oxidase of the yeast Saccharomyces cerevisiae by means of extragenic complementation.

Authors:  B Meunier; A M Colson
Journal:  FEBS Lett       Date:  1993-12-13       Impact factor: 4.124

9.  The unusual reversion properties of a mitochondrial mutation in the structural gene of subunit I of cytochrome oxidase of Saccharomyces cerevisiae reveal a probable histidine ligand of the redox center.

Authors:  P Netter; S Robineau; P Sirand-Pugnet; M O Fauvarque
Journal:  Curr Genet       Date:  1992-02       Impact factor: 3.886

10.  A novel type of + 1 frameshift suppressor: a base substitution in the anticodon stem of a yeast mitochondrial serine-tRNA causes frameshift suppression.

Authors:  A Hüttenhofer; B Weiss-Brummer; G Dirheimer; R P Martin
Journal:  EMBO J       Date:  1990-02       Impact factor: 11.598
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  1 in total

1.  Mutations in the mitochondrial split gene COXI are preferentially located in exons: a mapping study of 170 mutants.

Authors:  P Netter; S Robineau; C Lemaire
Journal:  Mol Gen Genet       Date:  1995-02-20
  1 in total

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