Literature DB >> 7874280

Acetylcholine regulates glucagon secretion from human glucagonoma cells.

A Funakoshi1, Y Yasunami, S Ryu, H Shinozaki, A Jimi, S Ikeda.   

Abstract

Human glucagonoma cells were isolated and maintained in vitro. Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels. Atropine abolished the stimulatory effect of Cch on glucagon, VIP, and PP release. An immunohistological study of the tumor tissues revealed that the cells contained glucagon, VIP, and PP. These findings demonstrate, for the first time, the in vitro release of glucagon from glucagonoma cells by Cch stimulation.

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Year:  1994        PMID： 7874280     DOI： 10.1007/bf02349291

Source DB:  PubMed          Journal:  J Gastroenterol        ISSN： 0944-1174            Impact factor:   7.527


  5 in total

1.  Plasma cholecystokinin and pancreatic polypeptide responses after ingestion of a liquid test meal rich in medium-chain fatty acids in patients with chronic pancreatitis.

Authors:  I Nakano; A Funakoshi; H Shinozaki; K Sakai
Journal:  Am J Clin Nutr       Date:  1989-02       Impact factor: 7.045

Review 2.  Pancreatic polypeptide: a hormone under vagal control.

Authors:  T W Schwartz
Journal:  Gastroenterology       Date:  1983-12       Impact factor: 22.682

3.  In vitro study of cultured human insulinoma cells: evidence of abnormal sensitivity to glucose.

Authors:  Y Yasunami; A Funakoshi; J Ono; K Miyazaki; A Jimi; K Konomi
Journal:  J Clin Endocrinol Metab       Date:  1987-07       Impact factor: 5.958

4.  A case of multiple endocrine neoplasia (MEN) type 1; the immunohistochemical and ultrastructural studies of its tumors and the analysis of hormones in tumor extracts.

Authors:  H Ishii; K Miyazaki; A Funakoshi; H Nawata; K Konomi; A Jimi
Journal:  Endocrinol Jpn       Date:  1989-02

5.  In vitro release of vasoactive intestinal polypeptide and pancreatic polypeptide from human VIPoma cells and its inhibition by somatostatin analogue (SMS 201-995).

Authors:  Y Yasunami; A Funakoshi; S Ryu; H Shinozaki; A Jimi; K Miyazaki; S Ikeda
Journal:  Surgery       Date:  1994-06       Impact factor: 3.982
  5 in total

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