| Literature DB >> 7874266 |
T Kuwabara1, M Otaka, H Itoh, A Zeniya, S Fujimori, S Otani, Y Tashima, O Masamune.
Abstract
Bowel dysfunction such as irritable bowel syndrome caused by stress is well described. Previous reports suggest that 5-hydroxytryptamine (5-HT) mediates alteration of bowel motility. In this study, the effects of water-immersion stress and the administration of 5-HT on the expression of a 60-kDa heat shock protein (HSP60) in rat colonic mucosa were investigated. The effect of YM-060, a 5-hydroxytryptamine 3 (5-HT3) receptor antagonist, on the expression of this protein was also studied. Water-immersion stress and the administration of 5-HT induced synthesis of HSP60 in rat colonic mucosa. The induction of HSP60 and the number of defecations were clearly inhibited by the oral administration of YM-060. Our results suggest that the induction of HSP60 in rat colonic mucosa by water-immersion stress may be associated with gastrointestinal motility mediated by 5-HT, especially via 5-HT3 receptors.Entities:
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Year: 1994 PMID： 7874266 DOI： 10.1007/bf02349277
Source DB: PubMed Journal: J Gastroenterol ISSN： 0944-1174 Impact factor: 7.527