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Literature DB >> 7872741

Effectiveness of various antimicrobial agents against Mycobacterium avium complex in the beige mouse model.

B Ji¹, N Lounis, C Truffot-Pernot, J Grosset.

Abstract

The results of five chemotherapeutic experiments in beige mice infected with organisms of the Mycobacterium avium complex are presented. After monotherapy with various antimicrobial agents for 4 weeks, only clarithromycin, amikacin, and ethambutol displayed definite bactericidal effects; sparfloxacin and clofazimine showed modest bacteriostatic effects; and rifampin and rifabutin were totally inactive against the isolate tested. After treatment for 4 weeks, the large quantities of clofazimine that had accumulated in the organs of mice seriously interfered with the enumeration of the CFU and assessment of the efficacy of the treatment. The in vitro synergistic effects of drug combinations against M. avium complex were not confirmed in beige mice. In combination with clarithromycin, amikacin could prevent the selection of clarithromycin-resistant mutants, whereas minocycline could not.

Entities: Chemical Species

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Year: 1994 PMID： 7872741 PMCID： PMC188235 DOI： 10.1128/AAC.38.11.2521

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

31 in total

1. Amikacin, ciprofloxacin, and imipenem treatment for disseminated Mycobacterium avium complex infection of beige mice.

Authors: C B Inderlied; P T Kolonoski; M Wu; L S Young
Journal: Antimicrob Agents Chemother Date: 1989-02 Impact factor: 5.191

2. Confirmation of the beige mouse model for study of disseminated infection with Mycobacterium avium complex.

Authors: M A Bertram; C B Inderlied; S Yadegar; P Kolanoski; J K Yamada; L S Young
Journal: J Infect Dis Date: 1986-07 Impact factor: 5.226

3. Antimicrobial synergism against Mycobacterium avium complex strains isolated from patients with acquired immune deficiency syndrome.

Authors: D M Yajko; J Kirihara; C Sanders; P Nassos; W K Hadley
Journal: Antimicrob Agents Chemother Date: 1988-09 Impact factor: 5.191

4. Activity of rifabutin alone or in combination with clofazimine or ethambutol or both against acute and chronic experimental Mycobacterium intracellulare infections.

Authors: P R Gangadharam; V K Perumal; B T Jairam; P N Rao; A K Nguyen; D C Farhi; M D Iseman
Journal: Am Rev Respir Dis Date: 1987-08

5. In vivo activity of amikacin alone or in combination with clofazimine or rifabutin or both against acute experimental Mycobacterium avium complex infections in beige mice.

Authors: P R Gangadharam; V K Perumal; N R Podapati; L Kesavalu; M D Iseman
Journal: Antimicrob Agents Chemother Date: 1988-09 Impact factor: 5.191

6. Synergistic effect of rifampin, streptomycin, ethionamide, and ethambutol on Mycobacterium intracellulare.

Authors: L B Heifets
Journal: Am Rev Respir Dis Date: 1982-01

7. In-vitro antimycobacterial activity of minocycline.

Authors: M Tsukamura
Journal: Tubercle Date: 1980-03

8. [Sterilizing activity of the main drugs on the mouse experimental tuberculosis (author's transl)].

Authors: J Grosset; C Truffot; J Fermanian; H Lecoeur
Journal: Pathol Biol (Paris) Date: 1982-06

9. In vitro synergistic activity of ethambutol, isoniazid, kanamycin, rifampin, and streptomycin against Mycobacterium avium-intracellulare complex.

Authors: B L Zimmer; D R DeYoung; G D Roberts
Journal: Antimicrob Agents Chemother Date: 1982-07 Impact factor: 5.191

10. Comparative in vitro activities of MDL 473, rifampin, and ansamycin against Mycobacterium intracellulare.

Authors: M H Cynamon
Journal: Antimicrob Agents Chemother Date: 1985-09 Impact factor: 5.191

23 in total

1. Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis.

Authors: Rokeya Tasneen; Si-Yang Li; Charles A Peloquin; Dinesh Taylor; Kathy N Williams; Koen Andries; Khisimuzi E Mdluli; Eric L Nuermberger
Journal: Antimicrob Agents Chemother Date: 2011-09-19 Impact factor: 5.191

Review 2. Pharmacokinetic and pharmacodynamic issues in the treatment of mycobacterial infections.

Authors: E Nuermberger; J Grosset
Journal: Eur J Clin Microbiol Infect Dis Date: 2004-03-13 Impact factor: 3.267

3. ATP synthase inhibition of Mycobacterium avium is not bactericidal.

Authors: Nacer Lounis; Tom Gevers; Joke Van den Berg; Luc Vranckx; Koen Andries
Journal: Antimicrob Agents Chemother Date: 2009-09-08 Impact factor: 5.191

4. Activities of isoniazid alone and in combination with other drugs against Mycobacterium avium infection in beige mice.

Authors: L Fattorini; Y Xiao; M Mattei; Y Li; E Iona; M L Ricci; O F Thoresen; R Creti; G Orefici
Journal: Antimicrob Agents Chemother Date: 1998-03 Impact factor: 5.191

10. Correlation between quinolone susceptibility patterns and sequences in the A and B subunits of DNA gyrase in mycobacteria.

Authors: I Guillemin; V Jarlier; E Cambau
Journal: Antimicrob Agents Chemother Date: 1998-08 Impact factor: 5.191