| Literature DB >> 7871638 |
H B Niell1, A M Mauer, D Rademacher.
Abstract
We investigated the activity of alpha-interferon (alpha-IFN), gamma-interferon (gamma-IFN) and tumor necrosis factor-alpha (TNF-alpha) in a panel of ten human bladder tumor cell lines. All cytokines were tested at concentrations of 100-10,000 U/ml in a clonogenic assay system. We found that alpha-IFN was active against five of the ten lines while gamma-IFN was only active against one line. TNF was active against five of the ten lines. Maximum synergisms were obtained between the alpha-IFN and TNF, occurring in nine of the ten cell lines. We conclude that alpha-IFN and TNF are active as single agents and synergistic when used together in vitro in human bladder tumor cell lines.Entities:
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Year: 1994 PMID： 7871638 DOI： 10.1007/bf00541901
Source DB: PubMed Journal: Urol Res ISSN： 0300-5623