Literature DB >> 7871004

Attenuation of some alcohol-induced mood changes and the desire to drink by 5-HT3 receptor blockade: a preliminary study in healthy male volunteers.

B A Johnson1, G M Campling, P Griffiths, P J Cowen.   

Abstract

We studied the effect of the 5-HT3 receptor antagonist ondansetron (4 mg orally) on some of the psychological effects of a small dose of alcohol (580 ml of 3.6% alcohol content by volume of lager) in 16 healthy male volunteers using a double-blind placebo controlled, Latin Square cross-over design. Pretreatment with ondansetron significantly attenuated several of the subjective pleasurable effects of alcohol, and also decreased the subjective desire to drink. These findings are consistent with preclinical studies suggesting that the reinforcing properties of alcohol may be attenuated by 5-HT3 receptor blockade.

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Year:  1993        PMID： 7871004     DOI： 10.1007/bf02247375

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  12 in total

1.  Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine.

Authors:  K M Wozniak; A Pert; M Linnoila
Journal:  Eur J Pharmacol       Date:  1990-10-09       Impact factor: 4.432

Review 2.  Drugs of abuse: anatomy, pharmacology and function of reward pathways.

Authors:  G F Koob
Journal:  Trends Pharmacol Sci       Date:  1992-05       Impact factor: 14.819

3.  MDL 72222, a selective 5-HT3 receptor antagonist, suppresses voluntary ethanol consumption in alcohol-preferring rats.

Authors:  F Fadda; B Garau; F Marchei; G Colombo; G L Gessa
Journal:  Alcohol Alcohol       Date:  1991       Impact factor: 2.826

4.  Effect of haloperidol on (+)-amphetamine self-administration.

Authors:  W M Davis; S G Smith
Journal:  J Pharm Pharmacol       Date:  1975-07       Impact factor: 3.765

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Authors:  R L Solomon; J D Corbit
Journal:  Psychol Rev       Date:  1974-03       Impact factor: 8.934

6.  Ethanol preferentially stimulates dopamine release in the nucleus accumbens of freely moving rats.

Authors:  G Di Chiara; A Imperato
Journal:  Eur J Pharmacol       Date:  1985-09-10       Impact factor: 4.432

7.  Alcohol-preferring rats: genetic sensitivity to alcohol-induced stimulation of dopamine metabolism.

Authors:  F Fadda; E Mosca; G Colombo; G L Gessa
Journal:  Physiol Behav       Date:  1990-04

Review 8.  Drugs of abuse: behavioural principles, methods and terms.

Authors:  I Stolerman
Journal:  Trends Pharmacol Sci       Date:  1992-05       Impact factor: 14.819

9.  Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens.

Authors:  K Yoshimoto; W J McBride; L Lumeng; T K Li
Journal:  Alcohol       Date:  1992 Jan-Feb       Impact factor: 2.405

10.  Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release.

Authors:  E Carboni; E Acquas; R Frau; G Di Chiara
Journal:  Eur J Pharmacol       Date:  1989-05-30       Impact factor: 4.432
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  19 in total

1.  Effects of ethanol on adenosine 5'-triphosphate-gated purinergic and 5-hydroxytryptamine receptors.

Authors:  Daryl L Davies; Liana Asatryan; Sacha T Kuo; John J Woodward; Brian F King; Ronald L Alkana; Cheng Xiao; Jiang Hong Ye; Hui Sun; Li Zhang; Xiang-Qun Hu; Volodya Hayrapetyan; David M Lovinger; Tina K Machu
Journal:  Alcohol Clin Exp Res       Date:  2006-02       Impact factor: 3.455

2.  5-HT3 receptor antagonism by ondansetron does not attenuate prolactin response to d-fenfluramine challenge in healthy human subjects.

Authors:  E F Coccaro; R J Kavoussi; T B Cooper; R Hauger
Journal:  Psychopharmacology (Berl)       Date:  1996-09       Impact factor: 4.530

3.  Ondansetron and alcohol pharmacokinetics.

Authors:  B A Johnson; J Rue; P J Cowen
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

Review 4.  Therapeutics of 5-HT3 receptor antagonists: current uses and future directions.

Authors:  Tina K Machu
Journal:  Pharmacol Ther       Date:  2011-02-26       Impact factor: 12.310

5.  Alcohols potentiate the function of 5-HT3 receptor-channels on NCB-20 neuroblastoma cells by favouring and stabilizing the open channel state.

Authors:  Q Zhou; T A Verdoorn; D M Lovinger
Journal:  J Physiol       Date:  1998-03-01       Impact factor: 5.182

Review 6.  Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment.

Authors:  Bankole A Johnson
Journal:  CNS Drugs       Date:  2004       Impact factor: 5.749

Review 7.  Recommended drug treatment strategies for the alcoholic patient.

Authors:  A Schaffer; C A Naranjo
Journal:  Drugs       Date:  1998-10       Impact factor: 9.546

Review 8.  Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings.

Authors:  Bankole A Johnson
Journal:  Biochem Pharmacol       Date:  2007-08-09       Impact factor: 5.858

9.  Acute and chronic administration of a low-dose combination of topiramate and ondansetron reduces ethanol's reinforcing effects in male alcohol preferring (P) rats.

Authors:  Catherine F Moore; Matthew D Lycas; Colin W Bond; Bankole A Johnson; Wendy J Lynch
Journal:  Exp Clin Psychopharmacol       Date:  2014-02       Impact factor: 3.157

10.  Effect of the 5-HT3 antagonist ondansetron on voluntary ethanol intake in rats and mice maintained on a limited access procedure.

Authors:  D M Tomkins; A D Le; E M Sellers
Journal:  Psychopharmacology (Berl)       Date:  1995-02       Impact factor: 4.530
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