Literature DB >> 7870944

Differential modification of the rewarding effects of methamphetamine and cocaine by opioids and antihistamines.

Y Masukawa1, T Suzuki, M Misawa.   

Abstract

We previously reported that the reinforcing effects of opioids are enhanced in combination with antihistamines. In the present study, effects of opioids and antihistamines on the reinforcing effects of psychostimulants such as methamphetamine and cocaine were investigated by utilizing the conditioned place preference procedure in rats. The place preference induced by methamphetamine was enhanced in combination with either morphine or chlorpheniramine, which produced additive and potentiative effects, respectively. In contrast, although the preference for cocaine was also enhanced by combination with these two drugs, morphine caused a potentiative effect and chlorpheniramine an additive one. In other words, the reinforcing effect of methamphetamine was differentially enhanced by opioids and antihistamines as compared to that of cocaine. These results suggest that the mechanism of reinforcing effect of methamphetamine is different from that of cocaine, resembling rather those of opioids.

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Year:  1993        PMID： 7870944     DOI： 10.1007/bf02245515

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  16 in total

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Authors:  T Suzuki; Y Masukawa; T Yoshii; T Kawai; S Yanaura
Journal:  Pharmacol Biochem Behav       Date:  1990-07       Impact factor: 3.533

10.  Potentiation of pentazocine conditioned place preference by tripelennamine in rats.

Authors:  T Suzuki; Y Masukawa; Y Shiozaki; M Misawa
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530
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  13 in total

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5.  Histidine-decarboxylase knockout mice show deficient nonreinforced episodic object memory, improved negatively reinforced water-maze performance, and increased neo- and ventro-striatal dopamine turnover.

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6.  Histaminergic activity in a rodent model of Parkinson's disease.

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7.  Abuse liability and stimulant properties of dextromethorphan and diphenhydramine combinations in rats.

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8.  Super-additive interaction of the reinforcing effects of cocaine and H1-antihistamines in rhesus monkeys.

Authors:  Zhixia Wang; William L Woolverton
Journal:  Pharmacol Biochem Behav       Date:  2008-10-07       Impact factor: 3.533

9.  The effects of the kappa agonist U-50,488 on cocaine-induced conditioned and unconditioned behaviors and Fos immunoreactivity.

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10.  Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice.

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