Literature DB >> 7868389

Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D.

X H Huang1, H Nishida, H Tomoda, N Tabata, K Shiomi, D J Yang, H Takayanagi, S Omura.   

Abstract

Structures of terpendoles A, B, C and D, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, were determined by spectroscopic studies. All terpendoles consist of diterpene and indole moieties in common. Terpendoles A, C and D possess an additional isoprenyl unit via oxygen atom(s) of their diterpene moieties. The relative stereochemistries of terpendoles C and D were confirmed by NOE experiments and X-ray crystallographic analysis.

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Year:  1995        PMID： 7868389     DOI： 10.7164/antibiotics.48.5

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  Identification and Structure Elucidation of Epoxyjanthitrems from Lolium perenne Infected with the Endophytic Fungus Epichloë festucae var. lolii and Determination of the Tremorgenic and Anti-Insect Activity of Epoxyjanthitrem I.

Authors:  Sarah C Finch; Michèle R Prinsep; Alison J Popay; Alistair L Wilkins; Nicola G Webb; Sweta Bhattarai; Joanne G Jensen; Allan D Hawkes; Jacob V Babu; Brian A Tapper; Geoffrey A Lane
Journal:  Toxins (Basel)       Date:  2020-08-17       Impact factor: 4.546

2.  New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-0440.

Authors:  Elyza Aiman Azizah Nur; Keisuke Kobayashi; Ai Amagai; Taichi Ohshiro; Hiroshi Tomoda
Journal:  Molecules       Date:  2020-07-06       Impact factor: 4.411

3.  Secondary Metabolites from the Endoparasitic Nematophagous Fungus Harposporium anguillulae YMF 1.01751.

Authors:  Zebao Dai; Yang Gan; Peiji Zhao; Guohong Li
Journal:  Microorganisms       Date:  2022-07-31

4.  Detection of oxygen addition peaks for terpendole E and related indole-diterpene alkaloids in a positive-mode ESI-MS.

Authors:  Yayoi Hongo; Takemichi Nakamura; Shunya Takahashi; Takayuki Motoyama; Toshiaki Hayashi; Hiroshi Hirota; Hiroyuki Osada; Hiroyuki Koshino
Journal:  J Mass Spectrom       Date:  2014-06       Impact factor: 1.982

5.  Toxic Indole Diterpenes from Endophyte-Infected Perennial Ryegrass Lolium perenne L.: Isolation and Stability.

Authors:  Priyanka Reddy; Myrna A Deseo; Vilnis Ezernieks; Kathryn Guthridge; German Spangenberg; Simone Rochfort
Journal:  Toxins (Basel)       Date:  2019-01-03       Impact factor: 4.546
  5 in total

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