Literature DB >> 786772

Effect of sodium amylosulfate (Depepsen) on the healing of duodenal ulcer.

K D Landecker, E M McCallum, D I Fevre, R Green, A Kasumi, D W Piper.   

Abstract

Thirty-five patients with active duodenal ulceration were included in a double blind randomized trial, the antiulcer agent sodium amylosulfate (Depepsen), being compared with placebo. Diagnosis and healing were determined by duodenoscopy. Results showed, in the whole series, 13 of 18 patients treated with Depepsen healed, whereas 10 of 17 healed on placebo (P = 0.04). In the group of 23 outpatients, 6 of 11 healed on Depepsen, and 5 of 12 healed on placebo (P = 0.55). It was concluded that Depepsen did not accelerate the healing of duodenal ulcer.

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Year:  1976        PMID: 786772

Source DB:  PubMed          Journal:  Gastroenterology        ISSN: 0016-5085            Impact factor:   22.682


  5 in total

1.  Graphical aid for determining power of clinical trials involving two groups.

Authors:  D K Miller; S M Homan
Journal:  BMJ       Date:  1988-09-10

2.  New drugs for peptic ulcer.

Authors: 
Journal:  Br Med J       Date:  1980-07-12

Review 3.  Sucralfate. A review of its pharmacodynamic properties and therapeutic use in peptic ulcer disease.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1984-03       Impact factor: 9.546

4.  Double-blind randomised clinical trial of a pepsin-inhibitory pentapeptide (pepstatin) in the treatment of duodenal ulcer.

Authors:  O Bonnevie; L B Svendsen; J Holst-Christensen; T S Johansen; J Søltoft; P M Christiansen
Journal:  Gut       Date:  1979-07       Impact factor: 23.059

5.  Reflux revisited: advancing the role of pepsin.

Authors:  Karna Dev Bardhan; Vicki Strugala; Peter W Dettmar
Journal:  Int J Otolaryngol       Date:  2011-11-10
  5 in total

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