Literature DB >> 7867666

Capillary electrophoresis and capillary electrophoresis-mass spectrometry in drug and metabolite analysis.

S Naylor1, A J Tomlinson, L M Benson, J W Gorrod.   

Abstract

The structural diversity of modern therapeutic agents can lead to labour intensive method development for each drug and the structural characterization of their metabolites. In this work, we show the benefits of the high resolution capabilities of capillary electrophoresis (CE) and demonstrate that nonaqueous CE and on-line CE-mass spectrometry (CE-MS) leads to enhanced resolution and recovery of mixtures containing the prototype H2-antagonist, mifentidine, and putative metabolites. Furthermore, the usefulness of CE-tandem MS (CE-MS/MS) is also demonstrated by the structural characterization of the novel N2-hydroxylamine metabolite of mifentidine.

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Year:  1994        PMID： 7867666     DOI： 10.1007/BF03188926

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  7 in total

1.  Separation of serotonin from catechols by capillary zone electrophoresis with electrochemical detection.

Authors:  R A Wallingford; A G Ewing
Journal:  Anal Chem       Date:  1989-01-15       Impact factor: 6.986

2.  Investigation of the metabolism of the neuroleptic drug haloperidol by capillary electrophoresis.

Authors:  A J Tomlinson; L M Benson; J P Landers; G F Scanlan; J Fang; J W Gorrod; S Naylor
Journal:  J Chromatogr A       Date:  1993-10-22       Impact factor: 4.759

3.  Investigation of the metabolic fate of the neuroleptic drug haloperidol by capillary electrophoresis-electrospray ionization mass spectrometry.

Authors:  A J Tomlinson; L M Benson; K L Johnson; S Naylor
Journal:  J Chromatogr       Date:  1993-11-24

4.  Investigation of the in vitro metabolism of the H2-antagonist mifentidine by on-line capillary electrophoresis-mass spectrometry using non-aqueous separation conditions.

Authors:  A J Tomlinson; L M Benson; J W Gorrod; S Naylor
Journal:  J Chromatogr B Biomed Appl       Date:  1994-07-15

5.  High-performance liquid chromatographic comparison of in vivo and in vitro drug metabolism.

Authors:  W Voelter; T Kronbach
Journal:  J Chromatogr       Date:  1984-05-04

6.  Investigation of drug metabolism using capillary electrophoresis with photodiode array detection and online mass spectrometry equipped with an array detector.

Authors:  A J Tomlinson; L M Benson; K L Johnson; S Naylor
Journal:  Electrophoresis       Date:  1994-01       Impact factor: 3.535

Review 7.  Capillary electrophoresis: a powerful microanalytical technique for biologically active molecules.

Authors:  J P Landers; R P Oda; T C Spelsberg; J A Nolan; K J Ulfelder
Journal:  Biotechniques       Date:  1993-01       Impact factor: 1.993
  7 in total
  2 in total

Review 1.  Capillary electrophoresis in pharmaceutical analysis.

Authors:  L A Holland; N P Chetwyn; M D Perkins; S M Lunte
Journal:  Pharm Res       Date:  1997-04       Impact factor: 4.200

2.  In vitro studies on the metabolic fate of mifentidine, a novel histamine H2-receptor antagonist.

Authors:  K Pattichis; M Kajbaf; J W Gorrod
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1997 Apr-Jun       Impact factor: 2.441
  2 in total

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