Literature DB >> 7866701

Animal models of Lyme disease: pathogenesis and immunoprophylaxis.

M T Philipp1, B J Johnson.   

Abstract

Valuable insights into the pathogenesis and immunoprophylaxis of Lyme disease are beginning to emerge from studies in animal models. This review highlights two animal models: the mouse, which has allowed us to investigate the role of both the immune response and spirochete phenotype in determining the outcome of the disease; and the Rhesus monkey, which manifests signs of nerve involvement, in addition to showing erythema migrans and arthritis.

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Year:  1994        PMID： 7866701     DOI： 10.1016/0966-842x(94)90800-1

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  26 in total

1.  Feeding of ticks on animals for transmission and xenodiagnosis in Lyme disease research.

Authors:  Monica E Embers; Britton J Grasperge; Mary B Jacobs; Mario T Philipp
Journal:  J Vis Exp       Date:  2013-08-31       Impact factor: 1.355

2.  Cloning and molecular characterization of plasmid-encoded antigens of Borrelia burgdorferi.

Authors:  J T Skare; D M Foley; S R Hernandez; D C Moore; D R Blanco; J N Miller; M A Lovett
Journal:  Infect Immun       Date:  1999-09       Impact factor: 3.441

3.  Induction of pro- and anti-inflammatory cytokines by Borrelia burgdorferi lipoproteins in monocytes is mediated by CD14.

Authors:  G H Giambartolomei; V A Dennis; B L Lasater; M T Philipp
Journal:  Infect Immun       Date:  1999-01       Impact factor: 3.441

4.  OspE-related, OspF-related, and Elp lipoproteins are immunogenic in baboons experimentally infected with Borrelia burgdorferi and in human lyme disease patients.

Authors:  P Scott Hefty; Chad S Brooks; Amy M Jett; Gary L White; Stephen K Wikel; Ronald C Kennedy; Darrin R Akins
Journal:  J Clin Microbiol       Date:  2002-11       Impact factor: 5.948

5.  Humoral immune response associated with lyme borreliosis in nonhuman primates: analysis by immunoblotting and enzyme-linked immunosorbent assay with sonicates or recombinant proteins.

Authors:  A R Pachner; D Dail; L Li; L Gurey; S Feng; E Hodzic; S Barthold
Journal:  Clin Diagn Lab Immunol       Date:  2002-11

6.  Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation.

Authors:  Aarti Gautam; Saurabh Dixit; Mario T Philipp; Shree R Singh; Lisa A Morici; Deepak Kaushal; Vida A Dennis
Journal:  Infect Immun       Date:  2011-09-26       Impact factor: 3.441

7.  Borrelia burgdorferi escape mutants that survive in the presence of antiserum to the OspA vaccine are killed when complement is also present.

Authors:  M Solé; C Bantar; K Indest; Y Gu; R Ramamoorthy; R Coughlin; M T Philipp
Journal:  Infect Immun       Date:  1998-06       Impact factor: 3.441

8.  Different classes of proteoglycans contribute to the attachment of Borrelia burgdorferi to cultured endothelial and brain cells.

Authors:  J M Leong; H Wang; L Magoun; J A Field; P E Morrissey; D Robbins; J B Tatro; J Coburn; N Parveen
Journal:  Infect Immun       Date:  1998-03       Impact factor: 3.441

9.  Cerebrospinal fluid-infiltrating CD4+ T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early lyme encephalitis.

Authors:  Jan D Lünemann; Harald Gelderblom; Mireia Sospedra; Jacqueline A Quandt; Clemencia Pinilla; Adriana Marques; Roland Martin
Journal:  Infect Immun       Date:  2006-10-23       Impact factor: 3.441

Review 10.  Biology of infection with Borrelia burgdorferi.

Authors:  Kit Tilly; Patricia A Rosa; Philip E Stewart
Journal:  Infect Dis Clin North Am       Date:  2008-06       Impact factor: 5.982
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