Literature DB >> 7865173

The antigonadotrophic effect of melatonin in Syrian hamsters is modulated by prostaglandin.

I Nir1, U Schmidt, N Zilber.   

Abstract

PGE2 was shown to play an essential role in the gonado-inhibiting effect of melatonin in Syrian hamsters by transforming the neuroendocrine signal to gonadal reactivity. Prostaglandin is a vital link in the transduction of photoperiodic information into gonadal function and the difference in its levels brought about by melatonin given at different times of the day could explain the phenomenon why gonadal involution occurs only upon administration of melatonin towards the end of the day. It appears also that the melatonin signal is decoded in the pituitary, probably involving the short loop negative feedback of LH on LH-RH hormones.

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Year:  1994        PMID： 7865173     DOI： 10.1007/bf01271564

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  10 in total

1.  Effect of melatonin on the reproductive systems of male and female Syrian hamsters: a diurnal rhythm in sensitivity to melatonin.

Authors:  L Tamarkin; W K Westrom; A I Hamill; B D Goldman
Journal:  Endocrinology       Date:  1976-12       Impact factor: 4.736

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Prostaglandin E2-induced release of luteinizing hormone-releasing factor (LRF).

Authors:  S R Ojeda; J E Wheaton; S M McCann
Journal:  Neuroendocrinology       Date:  1975       Impact factor: 4.914

4.  Prostaglandin E2-induced release of LHRH into hypophysial portal blood(1).

Authors:  R L Eskay; J Warberg; R S Mical; J C Porter
Journal:  Endocrinology       Date:  1975-10       Impact factor: 4.736

Review 5.  The pineal and its hormones in the control of reproduction in mammals.

Authors:  R J Reiter
Journal:  Endocr Rev       Date:  1980       Impact factor: 19.871

6.  Blockade of ovulation in the rat by a prostaglandin antogonist (N-0164).

Authors:  J H Botting; E A Linton; S A Whitehead
Journal:  J Endocrinol       Date:  1977-11       Impact factor: 4.286

7.  Release of E prostaglandins into the cerebrospinal fluid and its inhibition by melatonin after cervical stimulation in the rabbit.

Authors:  C M Leach; J A Reynoldson; G D Thorburn
Journal:  Endocrinology       Date:  1982-04       Impact factor: 4.736

8.  Pinealectomy and constant illumination increase the density of melatonin binding sites in the pars tuberalis of rodents.

Authors:  F Gauer; M Masson-Pévet; P Pévet
Journal:  Brain Res       Date:  1992-03-13       Impact factor: 3.252

9.  Prostaglandin E release by rat medial basal hypothalamus in vitro. Inhibition by melatonin at submicromolar concentrations.

Authors:  D P Cardinali; M N Ritta; A M Fuentes; M F Gimeno; A L Gimeno
Journal:  Eur J Pharmacol       Date:  1980-10-03       Impact factor: 4.432

10.  The effect of incomplete cerebral ischemia on prostaglandin levels in rat brain.

Authors:  E Shohami; J Rosenthal; S Lavy
Journal:  Stroke       Date:  1982 Jul-Aug       Impact factor: 7.914
  10 in total

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