Literature DB >> 7864876

Cloning and functional expression of human endothelin-converting enzyme cDNA.

K Shimada1, Y Matsushita, K Wakabayashi, M Takahashi, A Matsubara, Y Iijima, K Tanzawa.   

Abstract

Endothelin (ET) is a 21-residue potent vasoconstrictive peptide produced by vascular endothelial cells and formed from its precursor, big endothelin (big ET), by endothelin-converting enzyme (ECE). This paper describes the cloning and functional expression of a cDNA encoding a human ECE from human umbilical vein endothelial cells (HUVEC). Human ECE consists of 758 amino acid residues and has high homology to rat and bovine ECE. Immunoblot analysis using a monoclonal antibody risen against rat lung ECE showed the presence of immunoreactive protein in membrane fraction prepared from both HUVEC and COS-1 cells transfected with human ECE cDNA. Both COS-1 cells expressing human ECE and its membrane fraction converted big ET-1 most efficiently among big ETs.

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Year:  1995        PMID： 7864876     DOI： 10.1006/bbrc.1995.1258

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  22 in total

Review 1.  Secretory pathways in endothelin synthesis.

Authors:  F D Russell; A P Davenport
Journal:  Br J Pharmacol       Date:  1999-01       Impact factor: 8.739

2.  Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells.

Authors:  Yue Liu; Fei Ye; Kazunari Yamada; Jonathan L Tso; Yibei Zhang; David H Nguyen; Qinghua Dong; Horacio Soto; Jinny Choe; Anna Dembo; Hayley Wheeler; Ascia Eskin; Ingrid Schmid; William H Yong; Paul S Mischel; Timothy F Cloughesy; Harley I Kornblum; Stanley F Nelson; Linda M Liau; Cho-Lea Tso
Journal:  Mol Cancer Res       Date:  2011-10-19       Impact factor: 5.852

3.  Mutagenesis of Glu403 to Cys in rabbit neutral endopeptidase-24.11 (neprilysin) creates a disulphide-linked homodimer: analogy with endothelin-converting enzyme.

Authors:  M V Hoang; C E Sansom; A J Turner
Journal:  Biochem J       Date:  1997-11-01       Impact factor: 3.857

4.  Metallopeptide-promoted inactivation of angiotensin-converting enzyme and endothelin-converting enzyme 1: Toward dual-action therapeutics.

Authors:  Nikhil H Gokhale; J A Cowan
Journal:  J Biol Inorg Chem       Date:  2006-07-28       Impact factor: 3.358

5.  Recombinant human endothelin-converting enzyme ECE-1b is located in an intracellular compartment when expressed in polarized Madin-Darby canine kidney cells.

Authors:  A Azarani; G Boileau; P Crine
Journal:  Biochem J       Date:  1998-07-15       Impact factor: 3.857

6.  Ontogeny of endothelins-1 and -3, their receptors, and endothelin converting enzyme-1 in the early human embryo.

Authors:  M Brand; J M Le Moullec; P Corvol; J M Gasc
Journal:  J Clin Invest       Date:  1998-02-01       Impact factor: 14.808

7.  Modulation of human colon tumor-stromal interactions by the endothelin system.

Authors:  G Egidy; L Juillerat-Jeanneret; J F Jeannin; P Korth; F T Bosman; F Pinet
Journal:  Am J Pathol       Date:  2000-12       Impact factor: 4.307

8.  Regulation of the endothelin system by shear stress in human endothelial cells.

Authors:  H Morawietz; R Talanow; M Szibor; U Rueckschloss; A Schubert; B Bartling; D Darmer; J Holtz
Journal:  J Physiol       Date:  2000-06-15       Impact factor: 5.182

9.  Linkage mapping of the endothelin-converting enzyme gene (Ednce) to rat chromosome 5.

Authors:  A Y Deng; J P Rapp
Journal:  Mamm Genome       Date:  1995-10       Impact factor: 2.957

Review 10.  Endothelin-1 gene regulation.

Authors:  Lisa R Stow; Mollie E Jacobs; Charles S Wingo; Brian D Cain
Journal:  FASEB J       Date:  2010-09-13       Impact factor: 5.191
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