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Literature DB >> 786356

Phenylbutazone: a clinico-pharmacological study in rheumatoid arthritis.

Abstract

A clinical trial of phenylbutazone in high dose (300 mg daily) and low dose (50 mg daily) is presented. 2. By analysis of the data by different methods, significant differences in clinical efficacy were shown between the two therapeutic regimes. 3. A relationship between the clinical effect and plasma level of phenylbutazone was demonstrated. 4. Some problems in the interpretation of plasma level-clinical effect correlates are discussed.

Entities: Chemical Disease

Mesh：

Substances：
Phenylbutazone

Year: 1975 PMID： 786356 PMCID： PMC1402615 DOI： 10.1111/j.1365-2125.1975.tb00553.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

11 in total

1. Observations on the treatment of rheumatoid arthritis with butazolidin.

Authors: J P CURRIE; R A BROWN; G WILL
Journal: Ann Rheum Dis Date: 1953-06 Impact factor: 19.103

2. Drug treatment of rheumatic disorders in general practice. A comparative study of aspirin and an alkali-phenylbutazone preparation.

Authors: E Lewis-Faning; P D Fowler
Journal: Br J Clin Pract Date: 1971-03

3. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.

Authors: D M Ritchie; J A Boyle; J M McInnes; M K Jasani; T G Dalakos; P Grieveson; W W Buchanan
Journal: Q J Med Date: 1968-07

4. Drug therapy. Serum drug concentrations as therapeutic guides.

Authors: J Koch-Weser
Journal: N Engl J Med Date: 1972-08-03 Impact factor: 91.245

5. Assessment of drugs in out-patients with rheumatoid arthritis. Evaluation of methods and a comparison of mefenamic and flufenamic acids with phenylbutazone and aspirin.

Authors: R M Mason; D E Barnardo; W R Fox; M Weatherall
Journal: Ann Rheum Dis Date: 1967-09 Impact factor: 19.103

6. Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisone.

Authors: B B BRODIE; E W LOWMAN; J J BURNS; P R LEE; T CHENKIN; A GOLDMAN; M WEINER; J M STEELE
Journal: Am J Med Date: 1954-02 Impact factor: 4.965

7. The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material.

Authors: J J BURNS; R K ROSE; T CHENKIN; A GOLDMAN; A SCHULERT; B B BRODIE
Journal: J Pharmacol Exp Ther Date: 1953-11 Impact factor: 4.030

8. Genetic control of phenylbutazone metabolism in man.

Authors: J A Whittaker; D A Evans
Journal: Br Med J Date: 1970-11-07

9. Method for assessing therapeutic potential of anti-inflammatory antirheumatic drugs in rheumatoid arthritis.

Authors: P Lee; J Webb; J Anderson; W W Buchanan
Journal: Br Med J Date: 1973-06-23

10. Acetanilide oxidation in phenylbutazone-associated hypoplastic anaemia.

Authors: J L Cunningham; M J Leyland; I W Delamore; D A Evans
Journal: Br Med J Date: 1974-08-03

9 in total

Review 1. Variability in response to NSAIDs. Fact or fiction?

Authors: R O Day; G G Graham; K M Williams; P M Brooks
Journal: Drugs Date: 1988-12 Impact factor: 9.546

2. Comparative analgesic and anti-inflammatory properties of sodium salicylate and acetylsalicylic acid (aspirin) in rheumatoid arthritis.

Authors: S J Preston; M H Arnold; E M Beller; P M Brooks; W W Buchanan
Journal: Br J Clin Pharmacol Date: 1989-05 Impact factor: 4.335

Phenylbutazone: a clinico-pharmacological study in rheumatoid arthritis.

1. Observations on the treatment of rheumatoid arthritis with butazolidin.

2. Drug treatment of rheumatic disorders in general practice. A comparative study of aspirin and an alkali-phenylbutazone preparation.

3. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.

4. Drug therapy. Serum drug concentrations as therapeutic guides.

5. Assessment of drugs in out-patients with rheumatoid arthritis. Evaluation of methods and a comparison of mefenamic and flufenamic acids with phenylbutazone and aspirin.

6. Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisone.

7. The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material.

8. Genetic control of phenylbutazone metabolism in man.

9. Method for assessing therapeutic potential of anti-inflammatory antirheumatic drugs in rheumatoid arthritis.

10. Acetanilide oxidation in phenylbutazone-associated hypoplastic anaemia.

Review 1. Variability in response to NSAIDs. Fact or fiction?

2. Comparative analgesic and anti-inflammatory properties of sodium salicylate and acetylsalicylic acid (aspirin) in rheumatoid arthritis.

3. Quantitation of dose and concentration-effect relationships for fenclofenac in rheumatoid arthritis.

Review 4. Correlation plasma levels, NSAID and therapeutic response.

5. A phenylbutazone dose-finding study in rheumatoid arthritis.

Review 6. Clinical pharmacokinetics of phenylbutazone.

Review 7. Clinical pharmacokinetics of non-steroidal anti-inflammatory drugs.

8. A chronic dose-ranging study of the pharmacokinetics of phenylbutazone in rheumatoid arthritic patients.

9. Correlation between ketoprofen plasma levels and analgesic effect in acute lumbar pain and radicular pain.