| Literature DB >> 7860233 |
R C Flanigan1, J H Saiers, M Wolf, E H Kraut, A Y Smith, B Blumenstein, E D Crawford.
Abstract
The Southwest Oncology Group (SWOG) studied the response rate and toxicity of merbarone (1,000 mg/m2 IV continuous infusion days 1-5, q 21 days) in patients with advanced metastatic renal cell carcinoma. Among 36 eligible patients, there was one partial response for a response rate of 3% (95% C.I. 0.1-15%). There were no mixed responses. There were no treatment related deaths or adverse drug reactions. Significant anemia, diarrhea, and hypercalcemia were observed. Mild to moderate degrees of malaise/fatigue/lethargy, dizziness/vertigo, hyperglycemia, creatinine increase, nausea, vomiting, weight loss, pedal edema, dyspnea, and granulocytopenia were noted. Merbarone does not have significant activity as a single agent in advanced renal cell carcinoma.Entities:
Mesh：
Substances：
Year: 1994 PMID： 7860233 DOI： 10.1007/bf00874446
Source DB: PubMed Journal: Invest New Drugs ISSN： 0167-6997 Impact factor: 3.850