BACKGROUND: The role of mitochondrial inheritance in type 2 diabetes mellitus has received much attention recently. In this study, three existing datasets in Taiwan are analysed to examine this theory. METHODS: Two of the datasets were community surveys and one a hospital case series. Subjects who had information regarding their paternal or maternal diabetic status were selected for the present study. In the first dataset, 745 subjects had information about paternal diabetic status and 765 had information about maternal diabetic status. In the second dataset, 255 and 267 subjects had the paternal and maternal information, respectively. In the third, a total of 3625 subjects had information about both their paternal and maternal diabetic status. Diabetic status of the study subjects was determined by fasting plasma glucose levels and/or oral glucose tolerance test; their parental diabetic status was collected by interview. RESULTS: The three datasets consistently demonstrated a significantly elevated odds ratio (OR) for reporting maternal diabetes (OR = 2.64, 95% confidence interval: 1.12-5.71) in diabetic patients as compared to non-diabetic subjects. The reporting of paternal diabetes, however, was not significantly different between diabetics and non-diabetics. In addition, the OR for reporting paternal diabetes were not significantly different between groups of different age-at-onset. With respect to maternal history, the OR increased significantly when age-at-onset was younger (test-for-trend P < 0.001). CONCLUSIONS: Our findings support mitochondrial inheritance of type 2 diabetes mellitus in the human population. The age-modifying effect was also in accordance with the mitochondrial oxidative phosphorylation paradigm for degenerative diseases.
BACKGROUND: The role of mitochondrial inheritance in type 2 diabetes mellitus has received much attention recently. In this study, three existing datasets in Taiwan are analysed to examine this theory. METHODS: Two of the datasets were community surveys and one a hospital case series. Subjects who had information regarding their paternal or maternal diabetic status were selected for the present study. In the first dataset, 745 subjects had information about paternal diabetic status and 765 had information about maternal diabetic status. In the second dataset, 255 and 267 subjects had the paternal and maternal information, respectively. In the third, a total of 3625 subjects had information about both their paternal and maternal diabetic status. Diabetic status of the study subjects was determined by fasting plasma glucose levels and/or oral glucose tolerance test; their parental diabetic status was collected by interview. RESULTS: The three datasets consistently demonstrated a significantly elevated odds ratio (OR) for reporting maternal diabetes (OR = 2.64, 95% confidence interval: 1.12-5.71) in diabeticpatients as compared to non-diabetic subjects. The reporting of paternal diabetes, however, was not significantly different between diabetics and non-diabetics. In addition, the OR for reporting paternal diabetes were not significantly different between groups of different age-at-onset. With respect to maternal history, the OR increased significantly when age-at-onset was younger (test-for-trend P < 0.001). CONCLUSIONS: Our findings support mitochondrial inheritance of type 2 diabetes mellitus in the human population. The age-modifying effect was also in accordance with the mitochondrial oxidative phosphorylation paradigm for degenerative diseases.
Authors: Aldi T Kraja; Chunyu Liu; Jessica L Fetterman; Mariaelisa Graff; Christian Theil Have; Charles Gu; Lisa R Yanek; Mary F Feitosa; Dan E Arking; Daniel I Chasman; Kristin Young; Symen Ligthart; W David Hill; Stefan Weiss; Jian'an Luan; Franco Giulianini; Ruifang Li-Gao; Fernando P Hartwig; Shiow J Lin; Lihua Wang; Tom G Richardson; Jie Yao; Eliana P Fernandez; Mohsen Ghanbari; Mary K Wojczynski; Wen-Jane Lee; Maria Argos; Sebastian M Armasu; Ruteja A Barve; Kathleen A Ryan; Ping An; Thomas J Baranski; Suzette J Bielinski; Donald W Bowden; Ulrich Broeckel; Kaare Christensen; Audrey Y Chu; Janie Corley; Simon R Cox; Andre G Uitterlinden; Fernando Rivadeneira; Cheryl D Cropp; E Warwick Daw; Diana van Heemst; Lisa de Las Fuentes; He Gao; Ioanna Tzoulaki; Tarunveer S Ahluwalia; Renée de Mutsert; Leslie S Emery; A Mesut Erzurumluoglu; James A Perry; Mao Fu; Nita G Forouhi; Zhenglong Gu; Yang Hai; Sarah E Harris; Gibran Hemani; Steven C Hunt; Marguerite R Irvin; Anna E Jonsson; Anne E Justice; Nicola D Kerrison; Nicholas B Larson; Keng-Hung Lin; Latisha D Love-Gregory; Rasika A Mathias; Joseph H Lee; Matthias Nauck; Raymond Noordam; Ken K Ong; James Pankow; Amit Patki; Alison Pattie; Astrid Petersmann; Qibin Qi; Rasmus Ribel-Madsen; Rebecca Rohde; Kevin Sandow; Theresia M Schnurr; Tamar Sofer; John M Starr; Adele M Taylor; Alexander Teumer; Nicholas J Timpson; Hugoline G de Haan; Yujie Wang; Peter E Weeke; Christine Williams; Hongsheng Wu; Wei Yang; Donglin Zeng; Daniel R Witte; Bruce S Weir; Nicholas J Wareham; Henrik Vestergaard; Stephen T Turner; Christian Torp-Pedersen; Evie Stergiakouli; Wayne Huey-Herng Sheu; Frits R Rosendaal; M Arfan Ikram; Oscar H Franco; Paul M Ridker; Thomas T Perls; Oluf Pedersen; Ellen A Nohr; Anne B Newman; Allan Linneberg; Claudia Langenberg; Tuomas O Kilpeläinen; Sharon L R Kardia; Marit E Jørgensen; Torben Jørgensen; Thorkild I A Sørensen; Georg Homuth; Torben Hansen; Mark O Goodarzi; Ian J Deary; Cramer Christensen; Yii-Der Ida Chen; Aravinda Chakravarti; Ivan Brandslund; Klaus Bonnelykke; Kent D Taylor; James G Wilson; Santiago Rodriguez; Gail Davies; Bernardo L Horta; Bharat Thyagarajan; D C Rao; Niels Grarup; Victor G Davila-Roman; Gavin Hudson; Xiuqing Guo; Donna K Arnett; Caroline Hayward; Dhananjay Vaidya; Dennis O Mook-Kanamori; Hemant K Tiwari; Daniel Levy; Ruth J F Loos; Abbas Dehghan; Paul Elliott; Afshan N Malik; Robert A Scott; Diane M Becker; Mariza de Andrade; Michael A Province; James B Meigs; Jerome I Rotter; Kari E North Journal: Am J Hum Genet Date: 2018-12-27 Impact factor: 11.025
Authors: C H T Tam; Y Wang; J Luan; H M Lee; A O Y Luk; G E Tutino; P C Y Tong; A P S Kong; W Y So; J C N Chan; R C W Ma Journal: Nutr Diabetes Date: 2014-03-10 Impact factor: 5.097