Literature DB >> 7859830

Effects of cis-diamminedichloroplatinum II (cisplatin) on the splenic tissue of rats: a histoquantitative study.

Z Milićević1, V Slepcević, D Nikolić, V Zivanović, N M Milićević.   

Abstract

Histoquantitative methods were applied to study the changes of splenic structure and proportions of splenic tissue compartments in cisplatin-treated (6 mg/kg body wt) male Wistar rats. Six days after treatment the significant reduction of volume density of white pulp was observed, which was due to the very prominent decrease of volume density of follicles. The volume density of periarteriolar lymphatic sheaths did not change substantially. Volume density of the marginal zone was also significantly reduced. A significant increase of volume density of connective tissue was observed. Morphometrical parameters of the follicles were also markedly altered: the number of follicles per mm2 of spleen section area, the numerical density of the follicles in the spleen, and the total number of the follicles were significantly reduced.

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Year:  1994        PMID： 7859830     DOI： 10.1006/exmp.1994.1027

Source DB:  PubMed          Journal:  Exp Mol Pathol        ISSN： 0014-4800            Impact factor:   3.362


  6 in total

Review 1.  Specific hemosiderin deposition in spleen induced by a low dose of cisplatin: altered iron metabolism and its implication as an acute hemosiderin formation model.

Authors:  Yingze Wang; L V Juan; Xiaowei Ma; Dongliang Wang; Huili Ma; Yanzhong Chang; Guangjun Nie; Lee Jia; Xianglin Duan; Xing-Jie Liang
Journal:  Curr Drug Metab       Date:  2010-07       Impact factor: 3.731

2.  Slow recovery of follicular B cells and marginal zone B cells after chemotherapy: implications for humoral immunity.

Authors:  A Zandvoort; M E Lodewijk; P A Klok; P M Dammers; F G Kroese; W Timens
Journal:  Clin Exp Immunol       Date:  2001-05       Impact factor: 4.330

3.  Effects of early and late adverse experiences on morpho-quantitative characteristics of Sprague-Dawley rat spleen subjected to stress during adulthood.

Authors:  Bélgica Vásquez; Cristian Sandoval; Ricardo Luiz Smith; Mariano del Sol
Journal:  Int J Clin Exp Pathol       Date:  2015-04-01

4.  Biodegradable hybrid polymer micelles for combination drug therapy in ovarian cancer.

Authors:  Swapnil S Desale; Samuel M Cohen; Yi Zhao; Alexander V Kabanov; Tatiana K Bronich
Journal:  J Control Release       Date:  2013-05-09       Impact factor: 9.776

5.  Bone-Marrow-Derived Mesenchymal Stem Cells, Their Conditioned Media, and Olive Leaf Extract Protect against Cisplatin-Induced Toxicity by Alleviating Oxidative Stress, Inflammation, and Apoptosis in Rats.

Authors:  Mahrous A Ibrahim; Athar M Khalifa; Alaa A Mohamed; Rania A Galhom; Horeya E Korayem; Noha M Abd El-Fadeal; Ahmed Abd-Eltawab Tammam; Mohamed Mansour Khalifa; Osama S Elserafy; Rehab I Abdel-Karim
Journal:  Toxics       Date:  2022-09-06

6.  Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice.

Authors:  Hardeep S Oberoi; Natalia V Nukolova; Frederic C Laquer; Larisa Y Poluektova; Jiangeng Huang; Yazen Alnouti; Masanao Yokohira; Lora L Arnold; Alexander V Kabanov; Samuel M Cohen; Tatiana K Bronich
Journal:  Int J Nanomedicine       Date:  2012-06-08
  6 in total

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