Literature DB >> 785922

Enhancement of glucose-stimulated insulin secretion from isolated rat pancreatic islets by human insulin antibodies.

H J Hahn, R Menzel, H D Gottschling, D Jahr.   

Abstract

Isolated pancreatic rat islets incubated in vitro were used as a bioassay system for investigating the influence of human insulin antibodies on insulin secretion. Serum samples with different titres of insulin antibodies were obtained from juvenile diabetics after various periods of insulin therapy. The insulin secretion of isolated islets is enhanced by insulin antibodies and positively correlated to the measured antibody titres in serum.

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Year:  1976        PMID： 785922     DOI： 10.1530/acta.0.0830123

Source DB:  PubMed          Journal:  Acta Endocrinol (Copenh)        ISSN： 0001-5598


  5 in total

1.  Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

Authors:  W K Ward; D C Bolgiano; B McKnight; J B Halter; D Porte
Journal:  J Clin Invest       Date:  1984-10       Impact factor: 14.808

2.  Insulin antibodies in diabetic children treated with monocomponent porcine insulin from the onset: relationship to B-cell function and partial remission.

Authors:  J Ludvigsson
Journal:  Diabetologia       Date:  1984-02       Impact factor: 10.122

3.  Characterization of circulating insulin and proinsulin-binding antibodies in autoimmune hypoglycemia.

Authors:  J Goldman; D Baldwin; A H Rubenstein; D D Klink; W G Blackard; L K Fisher; T F Roe; J J Schnure
Journal:  J Clin Invest       Date:  1979-05       Impact factor: 14.808

4.  Stimulatory effect of serum from diabetic patients on insulin release from mouse pancreatic islets maintained in tissue culture.

Authors:  J H Nielsen; C Eff; T Deckert; A Andersson
Journal:  Diabetologia       Date:  1981       Impact factor: 10.122

5.  In vitro effect of exogenous insulin on insulin secretion. Studies with glucose, leucine, arginine, aminophylline and tolbutamide.

Authors:  E J Verspohl; M Händel; I Hagenloh; H P Ammon
Journal:  Acta Diabetol Lat       Date:  1982 Oct-Dec
  5 in total

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