Literature DB >> 7858852

Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619.

A J Sellers, M L Ashford.   

Abstract

NS 1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 microM, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.

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Year:  1994        PMID： 7858852      PMCID： PMC1510436          DOI： 10.1111/j.1476-5381.1994.tb17041.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

Review 1.  Properties and functions of ATP-sensitive K-channels.

Authors:  S J Ashcroft; F M Ashcroft
Journal:  Cell Signal       Date:  1990       Impact factor: 4.315

2.  K+ channel openers activate brain sulfonylurea-sensitive K+ channels and block neurosecretion.

Authors:  H Schmid-Antomarchi; S Amoroso; M Fosset; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

3.  Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels.

Authors:  M L Ashford; P R Boden; J M Treherne
Journal:  Pflugers Arch       Date:  1990-01       Impact factor: 3.657

4.  K+ channels openers prevent epilepsy induced by the bee venom peptide MCD.

Authors:  G Gandolfo; C Gottesmann; J N Bidard; M Lazdunski
Journal:  Eur J Pharmacol       Date:  1989-01-17       Impact factor: 4.432

Review 5.  The pharmacology of ATP-sensitive potassium channels.

Authors:  G Edwards; A H Weston
Journal:  Annu Rev Pharmacol Toxicol       Date:  1993       Impact factor: 13.820

6.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors:  O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal:  Pflugers Arch       Date:  1981-08       Impact factor: 3.657

7.  Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel.

Authors:  S Candia; M L Garcia; R Latorre
Journal:  Biophys J       Date:  1992-08       Impact factor: 4.033

8.  Lack of effect of potassium channel openers on ATP-modulated potassium channels recorded from rat ventromedial hypothalamic neurones.

Authors:  A J Sellers; P R Boden; M L Ashford
Journal:  Br J Pharmacol       Date:  1992-12       Impact factor: 8.739

9.  Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels.

Authors:  S Amoroso; H Schmid-Antomarchi; M Fosset; M Lazdunski
Journal:  Science       Date:  1990-02-16       Impact factor: 47.728
  9 in total
  5 in total

1.  BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery.

Authors:  H Yamamura; Y Ohi; K Muraki; M Watanabe; Y Imaizumi
Journal:  Br J Pharmacol       Date:  2001-02       Impact factor: 8.739

2.  Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels.

Authors:  Jillian N Noblet; Meredith K Owen; Adam G Goodwill; Daniel J Sassoon; Johnathan D Tune
Journal:  Arterioscler Thromb Vasc Biol       Date:  2015-04-02       Impact factor: 8.311

3.  A comparison of the effects of SCA40, NS 004 and NS 1619 on large conductance Ca(2+)-activated K+ channels in bovine tracheal smooth muscle cells in culture.

Authors:  S Macmillan; R D Sheridan; E R Chilvers; L Patmore
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

4.  Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig.

Authors:  A J Fox; P J Barnes; P Venkatesan; M G Belvisi
Journal:  J Clin Invest       Date:  1997-02-01       Impact factor: 14.808

5.  Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic pain.

Authors:  Shao-Rui Chen; You-Qing Cai; Hui-Lin Pan
Journal:  J Neurochem       Date:  2009-04-30       Impact factor: 5.372
  5 in total

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