| Literature DB >> 7858248 |
M Lafage-Pochitaloff1, M Alcalay, V Brunel, L Longo, D Sainty, J Simonetti, F Birg, P G Pelicci.
Abstract
Tumor-associated chromosome translocations usually lead to the formation of two reciprocal fusion genes: one thought to be involved in the transformation process, the other the mechanical consequence of the translocation event. In the case of acute promyelocytic leukemia (APL) blasts, the 15;17 chromosome translocation generates the putatively transforming PML/RARa fusion gene and its reciprocal RARa/PML. We report APL cases with submicroscopic 15;17 recombinations leading to the formation of nonreciprocal PML/RARa or RARa/PML fusion genes. Therefore, each of the two reciprocal translocation products may be independently formed and selected by the leukemic phenotype, implying that both are involved in tumorigenesis.Entities:
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Year: 1995 PMID： 7858248
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113