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Literature DB >> 7855890

The ins and outs of Raf kinases.

G Daum¹, I Eisenmann-Tappe, H W Fries, J Troppmair, U R Rapp.

Abstract

Raf kinases are signal-integrating enzymes that have the ability to switch tyrosine kinase signalling to serine/threonine phosphorylation and connect growth factor receptors with transcription factors. The connection involves a cascade of protein kinases that is essential for cellular proliferation and differentiation of species ranging from worms to humans. This cascade also mediates transformation by most oncogenes.

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Year: 1994 PMID： 7855890 DOI： 10.1016/0968-0004(94)90133-3

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

96 in total

1. S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.

Authors: A Chiloeches; C S Mason; R Marais
Journal: Mol Cell Biol Date: 2001-04 Impact factor: 4.272

2. The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases.

Authors: T Okada; C D Hu; T G Jin; K Kariya; Y Yamawaki-Kataoka; T Kataoka
Journal: Mol Cell Biol Date: 1999-09 Impact factor: 4.272

10. Association of yeast adenylyl cyclase with cyclase-associated protein CAP forms a second Ras-binding site which mediates its Ras-dependent activation.

Authors: F Shima; T Okada; M Kido; H Sen; Y Tanaka; M Tamada; C D Hu; Y Yamawaki-Kataoka; K Kariya; T Kataoka
Journal: Mol Cell Biol Date: 2000-01 Impact factor: 4.272

The ins and outs of Raf kinases.

1. S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.

2. The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases.

3. c-Raf regulates cell survival and retinal ganglion cell morphogenesis during neurogenesis.

4. Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases.

5. Identification of TH1 as an interaction partner of A-Raf kinase.

6. Structural view of a fungal toxin acting on a 14-3-3 regulatory complex.

Review 7. Cancer cell signaling pathways targeted by spice-derived nutraceuticals.

8. Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.

9. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

10. Association of yeast adenylyl cyclase with cyclase-associated protein CAP forms a second Ras-binding site which mediates its Ras-dependent activation.