| Literature DB >> 7855886 |
S M Feller1, R Ren, H Hanafusa, D Baltimore.
Abstract
The Src homology domains SH2 and SH3 are modular components present in many signal transduction proteins. They allow rapid formation of stable protein complexes and may also regulate protein function through intramolecular binding events. SH2 domains recognize phosphotyrosyl residues in a specific sequence context, while SH3 domains recognize a PxxP motif and additional residues that mediate binding specificity.Entities:
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Year: 1994 PMID： 7855886 DOI： 10.1016/0968-0004(94)90129-5
Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807