Literature DB >> 7855231

Seroquel (ICI 204,636) restores prepulse inhibition of acoustic startle in apomorphine-treated rats: Similarities to clozapine.

N R Swerdlow1, D Zisook, N Taaid.   

Abstract

Seroquel (ICI 204,636) is a mixed D2/5HT2 antagonist with a preclinical profile suggestive of potential antipsychotic efficacy. We compared seroquel to clozapine in an animal model of sensorimotor gating deficits in shizophrenic patients. Like schizophrenic patients, rats treated with apomophrine (APO) exhibit deficits in prepulse inhibition (PPI) of acoustic startle. The ability of antipsychotics to restore PPI in APO-treated rats correlates (Rs = 0.991) with their clinical potency. Seroquel and clozapine both restore PPI in APO-treated rats. Seroquel's restoration of PPI in apomorphine-treated rats follows simple monotonic ascending dose-response properties, and is not accompanied by consistent changes in startle reflex amplitude. Seroquel's profile in this PPI model mimics that of other antipsychotics.

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Year:  1994        PMID： 7855231     DOI： 10.1007/bf02245001

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  15 in total

1.  The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications.

Authors:  N R Swerdlow; S B Caine; D L Braff; M A Geyer
Journal:  J Psychopharmacol       Date:  1992-01       Impact factor: 4.153

2.  Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics.

Authors:  N R Swerdlow; D L Braff; M A Geyer; G F Koob
Journal:  Biol Psychiatry       Date:  1986-01       Impact factor: 13.382

3.  Prestimulus effects on human startle reflex in normals and schizophrenics.

Authors:  D Braff; C Stone; E Callaway; M Geyer; I Glick; L Bali
Journal:  Psychophysiology       Date:  1978-07       Impact factor: 4.016

4.  Gating and habituation of the startle reflex in schizophrenic patients.

Authors:  D L Braff; C Grillon; M A Geyer
Journal:  Arch Gen Psychiatry       Date:  1992-03

5.  The effects of haloperidol and clozapine on the disruption of sensorimotor gating induced by the noncompetitive glutamate antagonist MK-801.

Authors:  D C Hoffman; H Donovan; J V Cassella
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

6.  Seroquel: behavioral effects in conventional and novel tests for atypical antipsychotic drug.

Authors:  B M Migler; E J Warawa; J B Malick
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

Review 7.  Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients.

Authors:  N R Swerdlow; D L Braff; N Taaid; M A Geyer
Journal:  Arch Gen Psychiatry       Date:  1994-02

8.  Dopaminergic stimulation disrupts sensorimotor gating in the rat.

Authors:  R S Mansbach; M A Geyer; D L Braff
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

9.  Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia.

Authors:  N R Swerdlow; M A Geyer
Journal:  Pharmacol Biochem Behav       Date:  1993-03       Impact factor: 3.533

10.  Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat.

Authors:  N R Swerdlow; V A Keith; D L Braff; M A Geyer
Journal:  J Pharmacol Exp Ther       Date:  1991-02       Impact factor: 4.030
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  8 in total

Review 1.  Novel antipsychotics: issues and controversies. Typicality of atypical antipsychotics.

Authors:  E Stip
Journal:  J Psychiatry Neurosci       Date:  2000-03       Impact factor: 6.186

2.  Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation.

Authors:  Laura J Mosher; Roberto Cadeddu; Sabrina Yen; Jeffrey L Staudinger; Francesco Traccis; Stephen C Fowler; Jamie L Maguire; Marco Bortolato
Journal:  Psychoneuroendocrinology       Date:  2019-06-14       Impact factor: 4.905

Review 3.  Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next.

Authors:  Neal R Swerdlow; David L Braff; Mark A Geyer
Journal:  J Psychopharmacol       Date:  2016-08-18       Impact factor: 4.153

4.  Toward understanding the biology of a complex phenotype: rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists.

Authors:  N R Swerdlow; Z A Martinez; F M Hanlon; A Platten; M Farid; P Auerbach; D L Braff; M A Geyer
Journal:  J Neurosci       Date:  2000-06-01       Impact factor: 6.167

5.  Preattentional and attentional cognitive deficits as targets for treating schizophrenia.

Authors:  David L Braff; Gregory A Light
Journal:  Psychopharmacology (Berl)       Date:  2004-04-30       Impact factor: 4.530

Review 6.  Criteria for validating mouse models of psychiatric diseases.

Authors:  Kathryn K Chadman; Mu Yang; Jacqueline N Crawley
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2009-01-05       Impact factor: 3.568

7.  1-Methyl-1,2,3,4-tetrahydroisoquinoline antagonizes a rise in brain dopamine metabolism, glutamate release in frontal cortex and locomotor hyperactivity produced by MK-801 but not the disruptions of prepulse inhibition, and impairment of working memory in rat.

Authors:  Małgorzata Pietraszek; Jerzy Michaluk; Irena Romańska; Agnieszka Wasik; Krystyna Gołembiowska; Lucyna Antkiewicz-Michaluk
Journal:  Neurotox Res       Date:  2009-08-01       Impact factor: 3.911

8.  Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine.

Authors:  Andrew J Goudie; Judith A Smith; Mark J Millan
Journal:  Psychopharmacology (Berl)       Date:  2003-09-24       Impact factor: 4.530
  8 in total

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