Literature DB >> 7854795

Intrathecal morphine and clonidine in the management of spinal cord injury pain: a case report.

Philip J Siddall1, Megan Gray, Susan Rutkowski, Michael J Cousins.   

Abstract

Neuropathic pain following spinal cord injury (SCI) can be difficult to manage using currently available pain management techniques. We describe a case of chronic pain following SCI which failed to respond to a variety of approaches including intrathecal administration of morphine. Use of clonidine in addition to the morphine resulted in a marked decrease in pain. The use of intrathecal clonidine with or without opioids may present an effective alternative in the management of intractable SCI pain and other forms of neuropathic pain.

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Year:  1994        PMID: 7854795     DOI: 10.1016/0304-3959(94)90059-0

Source DB:  PubMed          Journal:  Pain        ISSN: 0304-3959            Impact factor:   6.961


  7 in total

Review 1.  Peripheral mechanisms of pain and analgesia.

Authors:  Christoph Stein; J David Clark; Uhtaek Oh; Michael R Vasko; George L Wilcox; Aaron C Overland; Todd W Vanderah; Robert H Spencer
Journal:  Brain Res Rev       Date:  2008-12-31

Review 2.  Pharmacologic treatment of neuropathic pain.

Authors:  M S Wallace
Journal:  Curr Pain Headache Rep       Date:  2001-04

Review 3.  Neuraxial infusion in patients with chronic intractable cancer and noncancer pain.

Authors:  R K Osenbach; S Harvey
Journal:  Curr Pain Headache Rep       Date:  2001-06

Review 4.  Spinal drug delivery.

Authors:  T S Grabow; D Derdzinski; P S Staats
Journal:  Curr Pain Headache Rep       Date:  2001-12

5.  Morphine and clonidine combination therapy improves therapeutic window in mice: synergy in antinociceptive but not in sedative or cardiovascular effects.

Authors:  Laura S Stone; Jonathan P German; Kelly F Kitto; Carolyn A Fairbanks; George L Wilcox
Journal:  PLoS One       Date:  2014-10-09       Impact factor: 3.240

6.  Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury.

Authors:  Yong-Jie Wang; Zhen-Xing Zuo; Cheng Wu; Li Liu; Zhi-Hui Feng; Xiang-Yao Li
Journal:  Front Mol Neurosci       Date:  2017-09-12       Impact factor: 5.639

7.  Morphine and clonidine synergize to ameliorate low back pain in mice.

Authors:  Maral Tajerian; Magali Millecamps; Laura S Stone
Journal:  Pain Res Treat       Date:  2012-04-23
  7 in total

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