Literature DB >> 7854322

Identification and characterization of regulatory elements in the phosphoenolpyruvate carboxykinase gene PCK1 of Saccharomyces cerevisiae.

M Proft1, D Grzesitza, K D Entian.   

Abstract

Phosphoenolpyruvate carboxykinase is a key enzyme in gluconeogenesis. The expression of the PCK1 gene in Saccharomyces cerevisiae is strictly regulated and dependent on the carbon source provided. Two upstream activation sites (UAS1PCK1 and UAS2PCK1) and one upstream repression site (URSPCK1) were localized by detailed deletion analysis. The efficacy of these three promoter elements when separated from each other was confirmed by investigations using heterologous promoter test plasmids. Activation mediated by UAS1PCK1 or UAS2PCK1 did not occur in the presence of glucose, indicating that these elements are essential for glucose derepression. The repressing effect caused by URSPCK1 was much stronger in glucose-grown cells than in ethanol-grown cells.

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Year:  1995        PMID： 7854322     DOI： 10.1007/bf00288610

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  28 in total

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Review 2.  Regulation of sugar utilization by Saccharomyces cerevisiae.

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5.  An optimized freeze-squeeze method for the recovery of DNA fragments from agarose gels.

Authors:  D Tautz; M Renz
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Authors:  A Schöler; H J Schüller
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Review 8.  Glucose repression: a complex regulatory system in yeast.

Authors:  K D Entian
Journal:  Microbiol Sci       Date:  1986-12

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Authors:  K D Entian; F K Zimmermann
Journal:  J Bacteriol       Date:  1982-09       Impact factor: 3.490

Review 10.  Glucose repression in the yeast Saccharomyces cerevisiae.

Authors:  R J Trumbly
Journal:  Mol Microbiol       Date:  1992-01       Impact factor: 3.501
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  16 in total

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5.  Engineering the biocatalytic selectivity of iridoid production in Saccharomyces cerevisiae.

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9.  Sip4, a Snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes.

Authors:  O Vincent; M Carlson
Journal:  EMBO J       Date:  1998-12-01       Impact factor: 11.598

Review 10.  Yeast carbon catabolite repression.

Authors:  J M Gancedo
Journal:  Microbiol Mol Biol Rev       Date:  1998-06       Impact factor: 11.056
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