Literature DB >> 7853953

Vitamin-D-receptor-gene polymorphisms and change in lumbar-spine bone mineral density.

S Ferrari1, R Rizzoli, T Chevalley, D Slosman, J A Eisman, J P Bonjour.   

Abstract

Common vitamin-D-receptor (VDR) gene allelic variants predict bone mineral density. We analysed VDR alleles and rate of change of lumbar-spine bone mineral density over 18 months in 72 elderly subjects. 9 BB homozygotes lost bone mineral density but 26 homozygotes for the alternative genotype (bb) did not (mean change -2.3 [SE 1.0] vs 0.9 [0.7]% per year, p < 0.05), irrespective of calcium intake. Among 37 heterozygotes (Bb), however, change in bone mineral density correlated with calcium intake (r = 0.35, p < 0.03). This association between a genetic marker and rate of bone loss in the elderly suggests that the effect of calcium intake on maintenance of bone mass could relate to VDR gene polymorphisms.

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Year:  1995        PMID： 7853953     DOI： 10.1016/s0140-6736(95)90404-2

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  28 in total

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