Literature DB >> 7853952

Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus.

B Myrup1, P M Hansen, T Jensen, A Kofoed-Enevoldsen, B Feldt-Rasmussen, J Gram, C Kluft, J Jespersen, T Deckert.   

Abstract

We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention.

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Year:  1995        PMID： 7853952     DOI： 10.1016/s0140-6736(95)90403-4

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  11 in total

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