A study of life events in mania.

After clinical recovery, 46 manic patients were screened for evidence of life events during a period of 6 months before the first episode of mania (DSMIIIR criteria) and 6 months after the episode. Within-patient group comparisons showed that patients who reported life events had a significantly higher presumptive mean stress score before manic episode as compared with the period after the illness. When life events were considered in relation to age, sex, marital status and family history of affective disorder, on a logistic regression equation, it was found that life events before mania were significantly associated with males and with a younger age of onset. The implications of these findings are discussed.