The molecular structure of human erythropoietin.

The molecular structure of EPO has been discussed, and the gradual emergence of information about EPO has been reviewed. The importance of certain regions of the molecule and of glycosylation to EPO's structure and function are clear. Although its nucleotide and amino acid sequences are known, its tertiary structure remains elusive. Antipeptide antibody and mutagenesis studies have increased our ability to study structure/function and certain spatial relationships. Undoubtedly, additional information will continue to become available in this exciting area, providing a better understanding of the mechanisms behind EPO's central role in erythropoiesis.