Literature DB >> 7852180

High frequency of cancer patients with abnormal assembly of the T cell receptor-CD3 complex in peripheral blood T lymphocytes.

Y Gunji1, S Hori, T Aoe, T Asano, T Ochiai, K Isono, T Saito.   

Abstract

Structural abnormality of T cell receptor (TCR)-CD3 complex on the cell surface was investigated in peripheral blood lymphocytes (PBL) from 55 cancer patients. In 24 of the 68 tests done on these patients, the CD3 zeta chain was not detected by immunoprecipitation with anti-CD3 epsilon monoclonal antibody (mAb), but was observed with anti-CD3 zeta mAb, suggesting that a high frequency of cancer patients possesses abnormal T cell receptor (TCR) complex in PBL. On the other hand, the total zeta chain was missing in several advanced cases. During follow-up of several patients, the zeta chain became undetectable after two or three months of cancer progression. It appears that immunosuppressive status can be monitored by analyzing the TCR-CD3 complex on the cell surface of PBL.

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Year:  1994        PMID： 7852180      PMCID： PMC5919393          DOI： 10.1111/j.1349-7006.1994.tb02927.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


T cell receptor monoclonal antibody peripheral blood lymphocytes the 7 chain of high‐affinity Fc receptor for IgE tumor‐infiltrating lymphocytes
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Authors:  H Ohno; S Ono; N Hirayama; S Shimada; T Saito
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7.  Lymphocyte apoptosis induced by Fas ligand- expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytes.

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8.  Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress.

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9.  Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex.

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