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Literature DB >> 7851774

Dosage compensation in sciarids is achieved by hypertranscription of the single X chromosome in males.

P R da Cunha¹, B Granadino, A L Perondini, L Sánchez.

Abstract

Dosage compensation refers to the process whereby females and males with different doses of sex chromosomes have similar amounts of products from sex chromosome-linked genes. We analyzed the process of dosage compensation in Sciara ocellaris, Diptera of the suborder Nematocera. By autoradiography and measurements of X-linked rRNA in females (XX) and males (XO), we found that the rate of transcription of the single X chromosome in males is similar to that of the two X chromosomes in females. This, together with the bloated appearance of the X chromosome in males, support the idea that in sciarids dosage compensation is accomplished by hypertranscription of the X chromosome in males.

Entities: Species

Mesh：

Substances：
DNA

Year: 1994 PMID： 7851774 PMCID： PMC1206227

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

12 in total

1. Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.

Authors: N Brockdorff; A Ashworth; G F Kay; P Cooper; S Smith; V M McCabe; D P Norris; G D Penny; D Patel; S Rastan
Journal: Nature Date: 1991-05-23 Impact factor: 49.962

2. Genetic analysis of X-chromosome dosage compensation in Caenorhabditis elegans.

Authors: P M Meneely; W B Wood
Journal: Genetics Date: 1987-09 Impact factor: 4.562

Review 3. Gene dosage compensation in Drosophila melanogaster.

Authors: J C Lucchesi; J E Manning
Journal: Adv Genet Date: 1987 Impact factor: 1.944

4. The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression.

Authors: P Jeppesen; B M Turner
Journal: Cell Date: 1993-07-30 Impact factor: 41.582

5. Arrangements and rearrangements of sequences flanking the two types of rDNA insertion in D. melanogaster.

Authors: H Roiha; J R Miller; L C Woods; D M Glover
Journal: Nature Date: 1981-04-30 Impact factor: 49.962

6. Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei.

Authors: B M Turner; A J Birley; J Lavender
Journal: Cell Date: 1992-04-17 Impact factor: 41.582

7. The organization, localization and nucleotide sequence of the histone genes of the midge Chironomus thummi.

Authors: T Hankeln; E R Schmidt
Journal: Chromosoma Date: 1991-10 Impact factor: 4.316

8. Caenorhabditis elegans compensates for the difference in X chromosome dosage between the sexes by regulating transcript levels.

Authors: B J Meyer; L P Casson
Journal: Cell Date: 1986-12-26 Impact factor: 41.582

9. Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila.

Authors: M Gorman; M I Kuroda; B S Baker
Journal: Cell Date: 1993-01-15 Impact factor: 41.582

10. Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation.

Authors: G F Kay; G D Penny; D Patel; A Ashworth; N Brockdorff; S Rastan
Journal: Cell Date: 1993-01-29 Impact factor: 41.582

6 in total

1. Evolution of dosage compensation in Diptera: the gene maleless implements dosage compensation in Drosophila (Brachycera suborder) but its homolog in Sciara (Nematocera suborder) appears to play no role in dosage compensation.

Authors: M F Ruiz; M R Esteban; C Doñoro; C Goday; L Sánchez
Journal: Genetics Date: 2000-12 Impact factor: 4.562

2. The gene Sex-lethal of the Sciaridae family (order Diptera, suborder Nematocera) and its phylogeny in dipteran insects.

Authors: Esther Serna; Eduardo Gorab; M Fernanda Ruiz; Clara Goday; José M Eirín-López; Lucas Sánchez
Journal: Genetics Date: 2004-10 Impact factor: 4.562