C Lox1, M Cañez, F DeLeon, J Dorsett, S Prien. 1. Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center, Lubbock.
Abstract
OBJECTIVE: To evaluate coagulation parameters during IVF cycles with elevated E2. DESIGN: Prospective clinical study. SETTING: Human volunteers in an IVF clinic. PATIENTS: Infertile women undergoing IVF procedures. INTERVENTIONS: Coagulation factors were measured in blood along with E2 and P after singular hMG or leuprolide acetate (LA) plus hMG up to 14 days after hCG. MAIN OUTCOME MEASURES: Plasma coagulation factors. RESULTS: Some coagulation factors were statistically but not clinically elevated after LA-hMG-induced hyperestrogenism. For the most part, this was not correlated with E2. CONCLUSION: This study suggests that endogenous E2 increases due to fertility drugs cause a molecular activation of some coagulation factors, which do not result in an increased thrombosis.
OBJECTIVE: To evaluate coagulation parameters during IVF cycles with elevated E2. DESIGN: Prospective clinical study. SETTING:Human volunteers in an IVF clinic. PATIENTS: Infertile women undergoing IVF procedures. INTERVENTIONS: Coagulation factors were measured in blood along with E2 and P after singular hMG or leuprolide acetate (LA) plus hMG up to 14 days after hCG. MAIN OUTCOME MEASURES: Plasma coagulation factors. RESULTS: Some coagulation factors were statistically but not clinically elevated after LA-hMG-induced hyperestrogenism. For the most part, this was not correlated with E2. CONCLUSION: This study suggests that endogenous E2 increases due to fertility drugs cause a molecular activation of some coagulation factors, which do not result in an increased thrombosis.