| Literature DB >> 7849379 |
T Yoshida1, J Suzumiya, H Katakami, N Kimura, S Hisano, M Kikuchi, M Okumura.
Abstract
We analyzed the parathyroid-related protein (PTH-rP) content in tissue specimens obtained from a 61-year-old man with hypercalcemia associated with lung metastasis from urinary bladder carcinoma using radioimmunoassay and immunohistochemistry. Radioimmunoassay showed that the PTH-rP content was higher in metastatic lung tumor tissue than in non-tumorous lung tissue. Immunohistochemical analysis revealed the presence of PTH-rP in tumor cells. Furthermore, proliferation of osteoclasts was found in bone marrow at autopsy. The results suggest that PTH-rP induced humoral hypercalcemia of malignancy in a patient with urinary bladder cancer.Entities:
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Year: 1994 PMID： 7849379 DOI： 10.2169/internalmedicine.33.673
Source DB: PubMed Journal: Intern Med ISSN： 0918-2918 Impact factor: 1.271