Literature DB >> 7849089

The tumor-promoting effect of wounding: a possible role for TGF-beta-induced stromal alterations.

M H Sieweke1, M J Bissell.   

Abstract

From clinical, chemical carcinogenesis and transgenic animal studies, it is evident that wounding has a tumor-promoting effect. We discuss the role of TGF-beta (with special emphasis on TGF-beta 1) in this process and suggest that stromal alterations during wound healing, induced by TGF-beta, can be an important determinant of tumor growth. A tumor and a wound both require similar stromal microenvironments. Thus, a chemically initiated or an oncogene-expressing cell could be complemented to grow into a tumor if it finds itself in a hospitable wound-healing stroma.

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Year:  1994        PMID： 7849089     DOI： 10.1615/critrevoncog.v5.i2-3.90

Source DB:  PubMed          Journal:  Crit Rev Oncog        ISSN： 0893-9675


  23 in total

Review 1.  The potential influence of radiation-induced microenvironments in neoplastic progression.

Authors:  M H Barcellos-Hoff
Journal:  J Mammary Gland Biol Neoplasia       Date:  1998-04       Impact factor: 2.673

2.  Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer".

Authors:  Michael P Lisanti; Ubaldo E Martinez-Outschoorn; Zhao Lin; Stephanos Pavlides; Diana Whitaker-Menezes; Richard G Pestell; Anthony Howell; Federica Sotgia
Journal:  Cell Cycle       Date:  2011-08-01       Impact factor: 4.534

Review 3.  Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?

Authors:  Mina J Bissell; Mark A Labarge
Journal:  Cancer Cell       Date:  2005-01       Impact factor: 31.743

4.  Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development.

Authors:  N Thomasset; A Lochter; C J Sympson; L R Lund; D R Williams; O Behrendtsen; Z Werb; M J Bissell
Journal:  Am J Pathol       Date:  1998-08       Impact factor: 4.307

Review 5.  Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development.

Authors:  Lidiya S Orlichenko; Derek C Radisky
Journal:  Clin Exp Metastasis       Date:  2008-02-20       Impact factor: 5.150

Review 6.  The role of fibroblasts in tumor behavior.

Authors:  M Grégoire; B Lieubeau
Journal:  Cancer Metastasis Rev       Date:  1995-12       Impact factor: 9.264

Review 7.  The role of tumour-stromal interactions in modifying drug response: challenges and opportunities.

Authors:  Douglas W McMillin; Joseph M Negri; Constantine S Mitsiades
Journal:  Nat Rev Drug Discov       Date:  2013-03       Impact factor: 84.694

Review 8.  Tumor reversion: correction of malignant behavior by microenvironmental cues.

Authors:  Paraic A Kenny; Mina J Bissell
Journal:  Int J Cancer       Date:  2003-12-10       Impact factor: 7.396

Review 9.  Targeting the tumor microenvironment.

Authors:  Paraic A Kenny; Genee Y Lee; Mina J Bissell
Journal:  Front Biosci       Date:  2007-05-01

10.  Breast cancer by proxy: can the microenvironment be both the cause and consequence?

Authors:  Lone Rønnov-Jessen; Mina J Bissell
Journal:  Trends Mol Med       Date:  2008-12-16       Impact factor: 11.951
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