Literature DB >> 7849085

Retroviral determinants of leukemogenesis.

G B Athas1, C R Starkey, L S Levy.   

Abstract

The slowly transforming, leukemogenic retroviruses of humans and other mammals induce malignant disease after prolonged latency but lack an oncogene to which their malignant potential can be attributed directly. The leukemogenic activity of these retroviruses can be attributed to at least three factors, including (1) transcriptional regulatory sequences in the long terminal repeat: (2) the insertional mutagenesis of cellular protooncogenes, thus activating their malignant potential; and (3) the actions of structural and regulatory proteins encoded by viral genes. The goal of this review is to summarize recent findings regarding the roles of these factors in retroviral leukemogenesis. The focus of the review is on the slowly transforming, leukemogenic retroviruses of mammals, including humans and experimental animals.

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Year:  1994        PMID： 7849085     DOI： 10.1615/critrevoncog.v5.i2-3.40

Source DB:  PubMed          Journal:  Crit Rev Oncog        ISSN： 0893-9675


  14 in total

1.  Tissue distribution and timing of appearance of polytropic envelope recombinants during infection with SL3-3 murine leukemia virus or its weakly pathogenic SL3DeltaMyb5 mutant.

Authors:  K Rulli; P A Lobelle-Rich; A Trubetskoy; J Lenz; L S Levy
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

2.  Sequence-specific and/or stereospecific constraints of the U3 enhancer elements of MCF 247-W are important for pathogenicity.

Authors:  N L DiFronzo; C A Holland
Journal:  J Virol       Date:  1999-01       Impact factor: 5.103

3.  The noncoding and surface envelope coding sequences of myeloblastosis-associated virus are respectively responsible for nephroblastoma development and renal hyperplasia.

Authors:  V Joliot; C Khelifi; M Wyers; G Dambrine; F Lasserre; P Lemercier; B Perbal
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

4.  Structure and function of the long terminal repeats of feline leukemia viruses derived from naturally occurring acute myeloid leukemias in cats.

Authors:  K Nishigaki; M Okuda; Y Endo; T Watari; H Tsujimoto; A Hasegawa
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

5.  The feline leukemia virus long terminal repeat contains a potent genetic determinant of T-cell lymphomagenicity.

Authors:  J Pantginis; R M Beaty; L S Levy; J Lenz
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

6.  Ikaros, a lymphoid-cell-specific transcription factor, contributes to the leukemogenic phenotype of a mink cell focus-inducing murine leukemia virus.

Authors:  Nancy L DiFronzo; Cheuk T Leung; Mark K Mammel; Katia Georgopoulos; Barbara J Taylor; Quynh N Pham
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

7.  The long terminal repeat of Jaagsiekte sheep retrovirus is preferentially active in differentiated epithelial cells of the lungs.

Authors:  M Palmarini; S Datta; R Omid; C Murgia; H Fan
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

8.  Importance of receptor usage, Fli1 activation, and mouse strain for the stem cell specificity of 10A1 murine leukemia virus leukemogenicity.

Authors:  Michaela Rodenburg; Meike Fischer; Afra Engelmann; Stephanie O Harbers; Marion Ziegler; Jürgen Löhler; Carol Stocking
Journal:  J Virol       Date:  2006-11-01       Impact factor: 5.103

Review 9.  Endogenous env elements: partners in generation of pathogenic feline leukemia viruses.

Authors:  P Roy-Burman
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332

10.  Pathogenicity induced by feline leukemia virus, Rickard strain, subgroup A plasmid DNA (pFRA).

Authors:  H Chen; M K Bechtel; Y Shi; A Phipps; L E Mathes; K A Hayes; P Roy-Burman
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103
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