J F Arroyo1, M L Cohen. 1. Department of Rheumatology, St. Vincent's Hospital, Sydney, NSW, Australia.
Abstract
OBJECTIVE: As disturbed nociception may be relevant to the pathogenesis of fibromyalgia, nonnoxious electrocutaneous stimulation was used as a tool to investigate nociceptive status. METHODS: Perception threshold and pain tolerance were studied in the upper limbs of 10 patients with fibromyalgia and 10 healthy volunteers. RESULTS: Perception threshold did not differ between the groups but the marked reduction in pain tolerance found in patients with fibromyalgia was accompanied by spread and persistence of dysesthesiae. CONCLUSION: The upper limbs of patients with fibromyalgia resembled regions of secondary hyperalgesia, which may imply that perturbation of central nociceptive mechanisms is involved in the pathogenesis of this syndrome.
OBJECTIVE: As disturbed nociception may be relevant to the pathogenesis of fibromyalgia, nonnoxious electrocutaneous stimulation was used as a tool to investigate nociceptive status. METHODS: Perception threshold and pain tolerance were studied in the upper limbs of 10 patients with fibromyalgia and 10 healthy volunteers. RESULTS: Perception threshold did not differ between the groups but the marked reduction in pain tolerance found in patients with fibromyalgia was accompanied by spread and persistence of dysesthesiae. CONCLUSION: The upper limbs of patients with fibromyalgia resembled regions of secondary hyperalgesia, which may imply that perturbation of central nociceptive mechanisms is involved in the pathogenesis of this syndrome.
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