OBJECTIVE: To evaluate family history as a risk factor for subarachnoid hemorrhage. DESIGN AND SETTING: A population-based case-control study in King County, Washington. SUBJECTS: Cases consisted of 149 patients with spontaneous subarachnoid hemorrhage. Two control subjects who were matched to cases by gender and age within 5 years were identified for each case using random digit telephone dialing. MAIN MEASURE: Detailed information on family history was obtained through an in-person interview. RESULTS: Some 11.4% of cases had a first-degree relative with a history of subarachnoid hemorrhage, compared with 6.4% of controls, yielding an odds ratio of 1.8 (95% CI, 0.92 to 3.7). The odds ratio for a positive family history among other relatives was 2.4 (95% CI, 1.1 to 5.2), likely reflecting family information bias. Findings were similar after adjustment was made for potential confounding variables, including cigarette smoking, a history of hypertension, and number of siblings and children. CONCLUSION: Although familial factors may be important in some families, overall they account for few cases of subarachnoid hemorrhage.
OBJECTIVE: To evaluate family history as a risk factor for subarachnoid hemorrhage. DESIGN AND SETTING: A population-based case-control study in King County, Washington. SUBJECTS: Cases consisted of 149 patients with spontaneous subarachnoid hemorrhage. Two control subjects who were matched to cases by gender and age within 5 years were identified for each case using random digit telephone dialing. MAIN MEASURE: Detailed information on family history was obtained through an in-person interview. RESULTS: Some 11.4% of cases had a first-degree relative with a history of subarachnoid hemorrhage, compared with 6.4% of controls, yielding an odds ratio of 1.8 (95% CI, 0.92 to 3.7). The odds ratio for a positive family history among other relatives was 2.4 (95% CI, 1.1 to 5.2), likely reflecting family information bias. Findings were similar after adjustment was made for potential confounding variables, including cigarette smoking, a history of hypertension, and number of siblings and children. CONCLUSION: Although familial factors may be important in some families, overall they account for few cases of subarachnoid hemorrhage.
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Authors: J E Bromberg; G J Rinkel; A Algra; P Greebe; C M van Duyn; D Hasan; M Limburg; H W ter Berg; E F Wijdicks; J van Gijn Journal: BMJ Date: 1995-07-29
Authors: Tatiana Foroud; Laura Sauerbeck; Robert Brown; Craig Anderson; Daniel Woo; Dawn Kleindorfer; Matthew L Flaherty; Ranjan Deka; Richard Hornung; Irene Meissner; Joan E Bailey-Wilson; Guy Rouleau; E Sander Connolly; Dongbing Lai; Daniel L Koller; John Huston; Joseph P Broderick Journal: Stroke Date: 2008-03-06 Impact factor: 7.914
Authors: Joseph P Broderick; Laura R Sauerbeck; Tatiana Foroud; John Huston; Nathan Pankratz; Irene Meissner; Robert D Brown Journal: BMC Med Genet Date: 2005-04-26 Impact factor: 2.103
Authors: Tatiana Foroud; Laura Sauerbeck; Robert Brown; Craig Anderson; Daniel Woo; Dawn Kleindorfer; Matthew L Flaherty; Ranjan Deka; Richard Hornung; Irene Meissner; Joan E Bailey-Wilson; Carl Langefeld; Guy Rouleau; E Sander Connolly; Dongbing Lai; Daniel L Koller; John Huston; Joseph P Broderick Journal: BMC Med Genet Date: 2009-01-13 Impact factor: 2.103