OBJECTIVE: To evaluate the frequency and outcome of liver transplantation for symptomatic, unresectable, benign hepatic neoplasms. DESIGN: Retrospective study. SETTING: Presbyterian University Hospital, a tertiary care referral center for liver transplantation affiliated with the University of Pittsburgh (Pa). PATIENTS: All 3239 liver transplant recipients at the University of Pittsburgh from January 1981 until January 1993. RESULTS: Twelve (0.37%) of 3239 patients required liver transplantation for benign, highly symptomatic hepatic neoplasms that were unresectable. Origins included adenoma (n = 6), mesenchymal hamartoma (n = 2), massive hepatic lymphangiomatosis (n = 1), hilar fibrous angiodysplasia (n = 1), focal nodular hyperplasia (n = 1), and hemangioma (n = 1). There were three perioperative deaths and two late deaths at 56 and 84 months. The remaining patients are alive, with follow-up ranging from 36 to 145 months. Median survival for the nine patients who survived the perioperative period is 88 months. The early deaths were attributable to hemorrhagic complications (n = 2) and necrotizing pancreatitis (n = 1). The two late deaths were due to disseminated aspergillosis and hepatitis-associated cirrhosis. CONCLUSION: Patients with severe symptoms from benign hepatic neoplasms that are not resectable can be treated by total hepatectomy and orthotopic liver transplantation, with the expectation of good long-term results.
OBJECTIVE: To evaluate the frequency and outcome of liver transplantation for symptomatic, unresectable, benign hepatic neoplasms. DESIGN: Retrospective study. SETTING: Presbyterian University Hospital, a tertiary care referral center for liver transplantation affiliated with the University of Pittsburgh (Pa). PATIENTS: All 3239 liver transplant recipients at the University of Pittsburgh from January 1981 until January 1993. RESULTS: Twelve (0.37%) of 3239 patients required liver transplantation for benign, highly symptomatic hepatic neoplasms that were unresectable. Origins included adenoma (n = 6), mesenchymal hamartoma (n = 2), massive hepatic lymphangiomatosis (n = 1), hilar fibrous angiodysplasia (n = 1), focal nodular hyperplasia (n = 1), and hemangioma (n = 1). There were three perioperative deaths and two late deaths at 56 and 84 months. The remaining patients are alive, with follow-up ranging from 36 to 145 months. Median survival for the nine patients who survived the perioperative period is 88 months. The early deaths were attributable to hemorrhagic complications (n = 2) and necrotizing pancreatitis (n = 1). The two late deaths were due to disseminated aspergillosis and hepatitis-associated cirrhosis. CONCLUSION:Patients with severe symptoms from benign hepatic neoplasms that are not resectable can be treated by total hepatectomy and orthotopic liver transplantation, with the expectation of good long-term results.
Authors: J C Hernández; C Alfonso; L González; M Samada; L Ramos; M Cepero-Valdez; A Antonio Abdo; F Gómez; R Castellanos; O López; J C Ugarte; J Jordán Journal: J Clin Pathol Date: 2006-05 Impact factor: 3.411
Authors: Undine G Lange; Julian N Bucher; Markus B Schoenberg; Christian Benzing; Moritz Schmelzle; Tanja Gradistanac; Steffen Strocka; Hans-Michael Hau; Michael Bartels Journal: World J Transplant Date: 2015-12-24
Authors: Giovanni Vennarecci; Roberto Santoro; Mario Antonini; Cecilia Ceribelli; Andrea Laurenzi; Enrico Moroni; Mirco Burocchi; Pasquale Lepiane; Giuseppe Maria Ettorre Journal: World J Hepatol Date: 2013-03-27