Literature DB >> 7847190

Superoxide dismutase inhibits interleukin-1-induced degradation of human cartilage.

K Fukuda1, H Dan, M Saitoh, M Takayama, S Tanaka.   

Abstract

Interleukin-1 (IL-1) is a key mediator in the pathogenesis of cartilage destruction in arthritis-related disorders. Human recombinant superoxide dismutase (SOD) blocked IL-1-mediated cartilage destruction but had no effect on IL-1-mediated changes in glycosaminoglycan and prostaglandin E2 synthesis. These data suggest that superoxide anions may be one factor of IL-1-mediated cartilage destruction.

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Year:  1994        PMID： 7847190     DOI： 10.1007/bf02014303

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

Review 1.  The effects of interleukin-1 on articular cartilage destruction as observed in arthritic diseases, and its therapeutic control.

Authors:  P J Verschure; C J Van Noorden
Journal:  Clin Exp Rheumatol       Date:  1990 May-Jun       Impact factor: 4.473

2.  Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines.

Authors:  M L Tiku; J B Liesch; F M Robertson
Journal:  J Immunol       Date:  1990-07-15       Impact factor: 5.422

3.  Oxygen radicals as effectors of cartilage destruction. Direct degradative effect on matrix components and indirect action via activation of latent collagenase from polymorphonuclear leukocytes.

Authors:  H Burkhardt; M Schwingel; H Menninger; H W Macartney; H Tschesche
Journal:  Arthritis Rheum       Date:  1986-03

4.  Increased superoxide anion release from chondrocytes in response to interleukin 1 and interferons.

Authors:  Y Iwasaki; Y Saegusa; T Matsubara; K Hirohata
Journal:  Nihon Seikeigeka Gakkai Zasshi       Date:  1990-10

5.  Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium.

Authors:  Y Okada; M Shinmei; O Tanaka; K Naka; A Kimura; I Nakanishi; M T Bayliss; K Iwata; H Nagase
Journal:  Lab Invest       Date:  1992-06       Impact factor: 5.662

6.  Biosynthesis and turnover of proteoglycans in organ culture of bovine articular cartilage.

Authors:  V C Hascall; T I Morales; G K Hascall; C J Handley; D J McQuillan
Journal:  J Rheumatol Suppl       Date:  1983-12

7.  A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures.

Authors:  R W Farndale; C A Sayers; A J Barrett
Journal:  Connect Tissue Res       Date:  1982       Impact factor: 3.417
  7 in total
  1 in total

1.  Plasminogen modulation of IL-1-stimulated degradation in bovine and human articular cartilage explants. The role of the endogenous inhibitors: PAI-1, alpha 2-antiplasmin, alpha 1-PI, alpha 2-macroglobulin and TIMP.

Authors:  J Oleksyszyn; A J Augustine
Journal:  Inflamm Res       Date:  1996-09       Impact factor: 4.575
  1 in total

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