Literature DB >> 7846116

Calcium antagonists and vasodilatation.

T Godfraind1.   

Abstract

Calcium antagonists comprise a diverse group of chemically unrelated agents that interact with voltage-operated calcium channels (L-type) and thereby inhibit smooth muscle contractility. They are used to treat several major cardiovascular disorders, including hypertension and angina pectoris; they are also studied in congestive heart failure and in atherosclerosis. The current view is that their therapeutic action is related to vasodilatation. This view is an oversimplification, as will be shown in this review. It will also be illustrated that all calcium antagonists are not identical pharmacological agents.

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Year:  1994        PMID： 7846116     DOI： 10.1016/0163-7258(94)90033-7

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  10 in total

1.  Effects of amlodipine and lacidipine on cardiac remodelling and renin production in salt-loaded stroke-prone hypertensive rats.

Authors:  J Kyselovic; P Krenek; M Wibo; T Godfraind
Journal:  Br J Pharmacol       Date:  2001-12       Impact factor: 8.739

Review 2.  Calcium antagonists and endothelial function: focus on nitric oxide and endothelin.

Authors:  T Godfraind; S Salomone
Journal:  Cardiovasc Drugs Ther       Date:  1996-09       Impact factor: 3.727

3.  Facilitation of the vasorelaxant action of calcium antagonists by basal nitric oxide in depolarized artery.

Authors:  S Salomone; C L Silva; N Morel; T Godfraind
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-10       Impact factor: 3.000

Review 4.  Regulation of TRPM2 channels in neutrophil granulocytes by ADP-ribose: a promising pharmacological target.

Authors:  Inka Heiner; Natalia Radukina; Jörg Eisfeld; Frank Kühn; Andreas Lückhoff
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-04       Impact factor: 3.000

5.  Pharmacological evidence of α2-adrenergic receptors in the hypotensive effect of Platonia insignis mart.

Authors:  Marcelo Bezerra Mendes; José Couras da Silva-Filho; Carla Kelly Barroso Sabino; Daniel Dias Rufino Arcanjo; Cleyton Marcos Melo Sousa; Isabella Cristhina Gonçalves Costa; Mariana Helena Chaves; Rita de Cássia Meneses Oliveira; Aldeídia P Oliveira
Journal:  J Med Food       Date:  2014-07-23       Impact factor: 2.786

6.  Adenine attenuates the Ca(2+) contraction-signaling pathway via adenine receptor-mediated signaling in rat vascular smooth muscle cells.

Authors:  Toshihiko Fukuda; Takahiro Kuroda; Miki Kono; Mai Hyoguchi; Satoshi Tajiri; Mitsuru Tanaka; Yoshinori Mine; Toshiro Matsui
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-06-18       Impact factor: 3.000

7.  Cell-volume-dependent vascular smooth muscle contraction: role of Na+, K+, 2Cl- cotransport, intracellular Cl- and L-type Ca2+ channels.

Authors:  Yana J Anfinogenova; Mikhail B Baskakov; Igor V Kovalev; Alexander A Kilin; Nickolai O Dulin; Sergei N Orlov
Journal:  Pflugers Arch       Date:  2004-10       Impact factor: 3.657

Review 8.  Lipophilic calcium antagonists in antiatherosclerotic therapy.

Authors:  S Bellosta; F Bernini
Journal:  Curr Atheroscler Rep       Date:  2000-01       Impact factor: 5.967

Review 9.  Discovery and Development of Calcium Channel Blockers.

Authors:  Théophile Godfraind
Journal:  Front Pharmacol       Date:  2017-05-29       Impact factor: 5.810

10.  Attenuation of L-type Ca²⁺ channel expression and vasomotor response in the aorta with age in both Wistar-Kyoto and spontaneously hypertensive rats.

Authors:  Toshihiko Fukuda; Takahiro Kuroda; Miki Kono; Takahisa Miyamoto; Mitsuru Tanaka; Toshiro Matsui
Journal:  PLoS One       Date:  2014-02-12       Impact factor: 3.240
  10 in total

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