Literature DB >> 7845623

Neuropathological phenotype and 'prion protein' genotype correlation in sporadic Creutzfeldt-Jakob disease.

R de Silva1, J W Ironside, L McCardle, T Esmonde, J Bell, R Will, O Windl, M Dempster, P Estibeiro, R Lathe.   

Abstract

A systematic study of 'prion protein' genotype in cases of sporadic Creutzfeldt-Jakob disease showing amyloid plaques staining with anti-prion protein antibody has been performed. This revealed a relative excess of cases with valine at position 129 of the gene's open reading frame. The observation emphasises the importance of this site of common polymorphism in influencing the neuropathological phenotype in human spongiform encephalopathy.

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Year:  1994        PMID： 7845623     DOI： 10.1016/0304-3940(94)90932-6

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  5 in total

1.  Increased incidence of sporadic Creutzfeldt-Jakob disease in the age groups between 70 and 90 years in Belgium.

Authors:  B Van Everbroeck; A Michotte; R Sciot; C Godfraind; M Deprez; S Quoilin; J-J Martin; P Cras
Journal:  Eur J Epidemiol       Date:  2006-07-12       Impact factor: 8.082

2.  Dissecting trait heterogeneity: a comparison of three clustering methods applied to genotypic data.

Authors:  Tricia A Thornton-Wells; Jason H Moore; Jonathan L Haines
Journal:  BMC Bioinformatics       Date:  2006-04-12       Impact factor: 3.169

Review 3.  Understanding Prion Strains: Evidence from Studies of the Disease Forms Affecting Humans.

Authors:  Marcello Rossi; Simone Baiardi; Piero Parchi
Journal:  Viruses       Date:  2019-03-29       Impact factor: 5.048

4.  Transmission characteristics of heterozygous cases of Creutzfeldt-Jakob disease with variable abnormal prion protein allotypes.

Authors:  Anne Ward; Jason R Hollister; Kristin McNally; Diane L Ritchie; Gianluigi Zanusso; Suzette A Priola
Journal:  Acta Neuropathol Commun       Date:  2020-06-09       Impact factor: 7.801

Review 5.  PMCA Applications for Prion Detection in Peripheral Tissues of Patients with Variant Creutzfeldt-Jakob Disease.

Authors:  Giorgio Giaccone; Fabio Moda
Journal:  Biomolecules       Date:  2020-03-05
  5 in total

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