Literature DB >> 7845607

Phosphatidylethanol formation and degradation in brains of acutely and repeatedly ethanol-treated rats.

C Lundqvist1, S Aradottir, C Alling, M C Boyano-Adanez, L Gustavsson.   

Abstract

The formation of the abnormal phospholipid phosphatidylethanol (PEth) was studied in hippocampus, cerebellum and cerebrum of rat brain after intraperitoneal ethanol administration. Prior to analysis by high performance thin layer chromatography PEth was purified. After one injection, PEth levels reached a maximum after 2 h and remained detectable for 14-24 h in all three regions. Repeated injections led to additional accumulation. Maximum in vivo levels of 30-50 nmol/g wet wt. were reached.

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Year:  1994        PMID: 7845607     DOI: 10.1016/0304-3940(94)90951-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN: 0304-3940            Impact factor:   3.046


  6 in total

1.  Phosphatidylethanol Detects Moderate-to-Heavy Alcohol Use in Liver Transplant Recipients.

Authors:  Michael Francis Fleming; Matthew J Smith; Erika Oslakovic; Michael R Lucey; Jenny X Vue; Patrice Al-Saden; Josh Levitsky
Journal:  Alcohol Clin Exp Res       Date:  2017-03-20       Impact factor: 3.455

2.  Phosphatidylethanol in Postmortem Brain and Serum Ethanol at Time of Death.

Authors:  Peter M Thompson; Nathalie Hill-Kapturczak; Marisa Lopez-Cruzan; Luis A Alvarado; Alok K Dwivedi; Martin A Javors
Journal:  Alcohol Clin Exp Res       Date:  2016-11-03       Impact factor: 3.455

3.  Carbohydrate deficient transferrin and alcoholism.

Authors:  Hilary Denis Solomons
Journal:  Germs       Date:  2012-06-01

4.  Distribution of Phosphatidylethanol in Maternal and Fetal Compartments After Chronic Gestational Binge Alcohol Exposure.

Authors:  Vishal Naik; Raine Lunde-Young; Josue Ramirez; Jehoon Lee; Jayanth Ramadoss
Journal:  Alcohol Clin Exp Res       Date:  2019-12-11       Impact factor: 3.455

Review 5.  Nonoxidative ethanol metabolism in humans-from biomarkers to bioactive lipids.

Authors:  Christoph Heier; Hao Xie; Robert Zimmermann
Journal:  IUBMB Life       Date:  2016-10-06       Impact factor: 3.885

Review 6.  Phosphatidylethanol in blood as a marker of chronic alcohol use: a systematic review and meta-analysis.

Authors:  Guido Viel; Rafael Boscolo-Berto; Giovanni Cecchetto; Paolo Fais; Alessandro Nalesso; Santo Davide Ferrara
Journal:  Int J Mol Sci       Date:  2012-11-13       Impact factor: 5.923

  6 in total

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