Literature DB >> 7845459

The structural basis of specific base-excision repair by uracil-DNA glycosylase.

R Savva1, K McAuley-Hecht, T Brown, L Pearl.   

Abstract

The 1.75-A crystal structure of the uracil-DNA glycosylase from herpes simplex virus type-1 reveals a new fold, distantly related to dinucleotide-binding proteins. Complexes with a trideoxynucleotide, and with uracil, define the DNA-binding site and allow a detailed understanding of the exquisitely specific recognition of uracil in DNA. The overall structure suggests binding models for elongated single- and double-stranded DNA substrates. Conserved residues close to the uracil-binding site suggest a catalytic mechanism for hydrolytic base excision.

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Year:  1995        PMID： 7845459     DOI： 10.1038/373487a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  93 in total

1.  Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation.

Authors:  S Datta; M M Prabu; M B Vaze; N Ganesh; N R Chandra; K Muniyappa; M Vijayan
Journal:  Nucleic Acids Res       Date:  2000-12-15       Impact factor: 16.971

2.  Efficient recognition of substrates and substrate analogs by the adenine glycosylase MutY requires the C-terminal domain.

Authors:  N H Chmiel; M P Golinelli; A W Francis; S S David
Journal:  Nucleic Acids Res       Date:  2001-01-15       Impact factor: 16.971

3.  A read-ahead function in archaeal DNA polymerases detects promutagenic template-strand uracil.

Authors:  M A Greagg; M J Fogg; G Panayotou; S J Evans; B A Connolly; L H Pearl
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

4.  Interactions of the human, rat, Saccharomyces cerevisiae and Escherichia coli 3-methyladenine-DNA glycosylases with DNA containing dIMP residues.

Authors:  M Saparbaev; J C Mani; J Laval
Journal:  Nucleic Acids Res       Date:  2000-03-15       Impact factor: 16.971

5.  Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation.

Authors:  T D Schneider
Journal:  Nucleic Acids Res       Date:  2001-12-01       Impact factor: 16.971

Review 6.  DNA glycosylases in the base excision repair of DNA.

Authors:  H E Krokan; R Standal; G Slupphaug
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

7.  Substitutions at tyrosine 66 of Escherichia coli uracil DNA glycosylase lead to characterization of an efficient enzyme that is recalcitrant to product inhibition.

Authors:  Narottam Acharya; Ramappa K Talawar; K Saikrishnan; M Vijayan; Umesh Varshney
Journal:  Nucleic Acids Res       Date:  2003-12-15       Impact factor: 16.971

8.  Unusual 2-aminopurine fluorescence from a complex of DNA and the EcoKI methyltransferase.

Authors:  T-J Su; B A Connolly; C Darlington; R Mallin; D T F Dryden
Journal:  Nucleic Acids Res       Date:  2004-04-23       Impact factor: 16.971

Review 9.  Overview of base excision repair biochemistry.

Authors:  Yun-Jeong Kim; David M Wilson
Journal:  Curr Mol Pharmacol       Date:  2012-01       Impact factor: 3.339

10.  Comparative genomic sequence analysis between a standard challenge strain and a vaccine strain of duck enteritis virus in China.

Authors:  Chenghuai Yang; Qihong Li; Junping Li; Guangchuan Zhang; Huijiao Li; Yecai Xia; Hanchun Yang; Kangzhen Yu
Journal:  Virus Genes       Date:  2013-11-28       Impact factor: 2.332
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