Literature DB >> 7845378

Effect of aluminium (Al) on brain mitochondrial monoamine oxidase-A (MAO-A) activity--an in vitro kinetic study.

K S Rao1, G V Rao.   

Abstract

Effect of aluminium (Al) on rat brain mitochondrial monoamine oxidase-A (MAO-A) was studied in vitro at three different pH (4.0, 7.4 and 9.0) values. The results have shown that Al is a non-competitive inhibitor for MAO-A. The data also showed that MAO-A inhibition by Al varies with free Al3+ concentration and different forms of Al under different pH conditions. Al altered the maximum velocity (Vmax) of MAO-A but did not affect substrate-enzyme affinity (Km). Al formed a strong chelation with the substrate (Kynuramine) (1:1).

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Year:  1994        PMID： 7845378     DOI： 10.1007/bf00926039

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  12 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Human monoamine oxidase. Lack of brain and platelet correlation.

Authors:  W F Young; E R Laws; F W Sharbrough; R M Weinshilboum
Journal:  Arch Gen Psychiatry       Date:  1986-06

3.  The metabolism of rat brain mitochondria. Preparation and characterization.

Authors:  J B Clark; W J Nicklas
Journal:  J Biol Chem       Date:  1970-09-25       Impact factor: 5.157

4.  Metal chelates in the storage and transport of neurotransmitters: formation of mixed ligand chelates of Mg 2+ -ATP with biogenic amines.

Authors:  K S Rajan; J M Davis; R W Colburn; F H Jarke
Journal:  J Neurochem       Date:  1972-04       Impact factor: 5.372

5.  Investigations of the interaction of aluminum with bovine plasma monoamine oxidase.

Authors:  Y Tsuzuki; J K Marquis
Journal:  Bull Environ Contam Toxicol       Date:  1985-03       Impact factor: 2.151

6.  Chemical softness and acute metal toxicity in mice and Drosophila.

Authors:  M W Williams; J D Hoeschele; J E Turner; K B Jacobson; N T Christie; C L Paton; L H Smith; H R Witschi; E H Lee
Journal:  Toxicol Appl Pharmacol       Date:  1982-05       Impact factor: 4.219

7.  Monoamine oxidase A and B: a useful concept?

Authors:  T J Mantle; K F Tipton
Journal:  Biochem Pharmacol       Date:  1978-01-01       Impact factor: 5.858

8.  A rapid microfluorimetric determination of monoamine oxidase.

Authors:  M Krajl
Journal:  Biochem Pharmacol       Date:  1965-11       Impact factor: 5.858

Review 9.  The chemistry of aluminum as related to biology and medicine.

Authors:  R B Martin
Journal:  Clin Chem       Date:  1986-10       Impact factor: 8.327

Review 10.  Mechanism of Alzheimer's disease: arguments for a neurotransmitter-aluminium complex implication.

Authors:  R Deloncle; O Guillard
Journal:  Neurochem Res       Date:  1990-12       Impact factor: 3.996
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  4 in total

1.  Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses.

Authors:  Masahiro Kawahara; Midori Kato-Negishi
Journal:  Int J Alzheimers Dis       Date:  2011-03-08

2.  A Toxic Synergy between Aluminium and Amyloid Beta in Yeast.

Authors:  Jamieson B Mcdonald; Sudip Dhakal; Ian Macreadie
Journal:  Int J Mol Sci       Date:  2021-02-12       Impact factor: 5.923

Review 3.  Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders.

Authors:  Hong Cheng; Bobo Yang; Tao Ke; Shaojun Li; Xiaobo Yang; Michael Aschner; Pan Chen
Journal:  Toxics       Date:  2021-06-17

4.  Comparison of total ionic strength adjustment buffers III and IV in the measurement of fluoride concentration of teas.

Authors:  Shilpa Patel; Narges Omid; Fatemeh V Zohoori; Anne Maguire; Kevin J Waldron; Ruth A Valentine
Journal:  Nutr Health       Date:  2018-04-04
  4 in total

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