Literature DB >> 7844526

Comparative analysis of fourteen individual human cytomegalovirus proteins for helper T cell response.

J Beninga1, B Kropff, M Mach.   

Abstract

The potential of selected proteins of human cytomegalovirus (HCMV) to induce a helper T (Th) cell immune response was investigated in healthy HCMV-seropositive donors. Recombinant derived glycoproteins B (gpUL55), H (gpUL75), integral membrane protein (pUL100), the US6-US11 glycoprotein family (pUS6-US11), the matrix proteins pp65 (ppUL83), pp28 (ppUL99) and the immediate early proteins IE1 (pUL123), IE2 (pUL122) and UL69 (pUL69) were used as stimulating antigens in a lymphocyte proliferation assay. The antigen-specific proliferative response was measured in HCMV-specific T cell lines (phenotype CD4+ CD8-) generated from five donors by stimulation of peripheral blood mononuclear cells with purified HCMV or HCMV-infected fibroblasts. A proliferative T cell response was induced by pp65, gB, gH, IE1, IE2 and UL69, with a dominant response to pp65 in all donors. Three T cell lines responded to gB and gH, respectively. For IE1, IE2 and UL69 a T cell stimulation could be demonstrated in single cell lines generated with lysate of HCMV-infected fibroblasts.

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Year:  1995        PMID： 7844526     DOI： 10.1099/0022-1317-76-1-153

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  14 in total

1.  Physical function impairment of older, HIV-infected adults is associated with cytomegalovirus immunoglobulin response.

Authors:  Kristine M Erlandson; Amanda A Allshouse; Eric Rapaport; Brent E Palmer; Cara C Wilson; Adriana Weinberg; Samantha MaWhinney; Thomas B Campbell
Journal:  AIDS Res Hum Retroviruses       Date:  2015-07-08       Impact factor: 2.205

Review 2.  CMV-specific immune reconstitution following allogeneic stem cell transplantation.

Authors:  Emily Blyth; Barbara Withers; Leighton Clancy; David Gottlieb
Journal:  Virulence       Date:  2016-08-09       Impact factor: 5.882

3.  Identification, analysis, and evolutionary relationships of the putative murine cytomegalovirus homologs of the human cytomegalovirus UL82 (pp71) and UL83 (pp65) matrix phosphoproteins.

Authors:  L D Cranmer; C L Clark; C S Morello; H E Farrell; W D Rawlinson; D H Spector
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

4.  In vivo replication, latency, and immunogenicity of murine cytomegalovirus mutants with deletions in the M83 and M84 genes, the putative homologs of human cytomegalovirus pp65 (UL83).

Authors:  C S Morello; L D Cranmer; D H Spector
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

Review 5.  Generation and maintenance of human memory cells during viral infection.

Authors:  Rabih Halwani; Mehrnoosh Doroudchi; Bader Yassine-Diab; Loury Janbazian; Yu Shi; Elias A Said; Elias K Haddad; Rafick-Pierre Sékaly
Journal:  Springer Semin Immunopathol       Date:  2006-09-12

6.  Ex vivo stimulation and expansion of both CD4(+) and CD8(+) T cells from peripheral blood mononuclear cells of human cytomegalovirus-seropositive blood donors by using a soluble recombinant chimeric protein, IE1-pp65.

Authors:  J Vaz-Santiago; J Lulé; P Rohrlich; C Jacquier; N Gibert; E Le Roy; D Betbeder; J L Davignon; C Davrinche
Journal:  J Virol       Date:  2001-09       Impact factor: 5.103

7.  Escape of human cytomegalovirus from HLA-DR-restricted CD4(+) T-cell response is mediated by repression of gamma interferon-induced class II transactivator expression.

Authors:  E Le Roy; A Mühlethaler-Mottet; C Davrinche; B Mach; J L Davignon
Journal:  J Virol       Date:  1999-08       Impact factor: 5.103

8.  Impaired peripheral Th1 CD4+ T cell response to Escherichia coli proteins in patients with Crohn's disease and ankylosing spondylitis.

Authors:  Asgar Ergin; Uta Syrbe; Rebecca Scheer; Andreas Thiel; Thomas Adam; Konrad Büssow; Rainer Duchmann; Martin Zeitz; Joachim Sieper
Journal:  J Clin Immunol       Date:  2011-09-08       Impact factor: 8.317

9.  Dense bodies of human cytomegalovirus induce both humoral and cellular immune responses in the absence of viral gene expression.

Authors:  S Pepperl; J Münster; M Mach; J R Harris; B Plachter
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

Review 10.  Tegument proteins of human cytomegalovirus.

Authors:  Robert F Kalejta
Journal:  Microbiol Mol Biol Rev       Date:  2008-06       Impact factor: 11.056
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