Literature DB >> 7844033

Novel antibiotics SF2738A, B and C, and their analogs produced by Streptomyces sp.

S Gomi1, S Amano, E Sato, S Miyadoh, Y Kodama.   

Abstract

Three new antibiotics SF2738A, B and C, and their analogs were isolated from the culture broth of Streptomyces sp. The antibiotics are active against Gram-positive bacteria, Gram-negative bacteria and fungi, and exhibited cytotoxic activity against P388 murine leukemia cells with IC50 values of 0.08, 0.25 and 7.5 micrograms/ml, respectively. Their structures were determined by spectral analyses and chemical conversion. Especially, the structure of SF2738A was confirmed to be (E)-((4-methoxy-5-methylthio-2-(2-pyridyl)pyridin-6-yl)methylene)azan ol by X-ray crystallographic analysis.

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Year:  1994        PMID： 7844033     DOI： 10.7164/antibiotics.47.1385

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  9 in total

1.  Biocontrol of toxinogenic Aspergillus flavus and Fusarium oxysporum f. sp. albedinis by two rare Saharan actinomycetes strains and LC-ESI/MS-MS profiling of their antimicrobial products.

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Journal:  Saudi J Biol Sci       Date:  2022-04-21       Impact factor: 4.052

2.  Anti-mycobacterial nucleoside antibiotics from a marine-derived Streptomyces sp. TPU1236A.

Authors:  Ying-Yue Bu; Hiroyuki Yamazaki; Kazuyo Ukai; Michio Namikoshi
Journal:  Mar Drugs       Date:  2014-12-17       Impact factor: 5.118

3.  Proteomic profiling reveals that collismycin A is an iron chelator.

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Journal:  Sci Rep       Date:  2016-12-06       Impact factor: 4.379

4.  Collismycin C from the Micronesian Marine Bacterium Streptomyces sp. MC025 Inhibits Staphylococcus aureus Biofilm Formation.

Authors:  Jin-Hyung Lee; Eonmi Kim; Hyukjae Choi; Jintae Lee
Journal:  Mar Drugs       Date:  2017-12-12       Impact factor: 5.118

5.  Characterization of the metallo-dependent amidohydrolases responsible for "auxiliary" leucinyl removal in the biosynthesis of 2,2'-bipyridine antibiotics.

Authors:  Ming Chen; Bo Pang; Ya-Nan Du; Yi-Peng Zhang; Wen Liu
Journal:  Synth Syst Biotechnol       Date:  2017-07-13

6.  Cytotoxic and Optically Active Pyrisulfoxins From the Endophytic Streptomyces albolongus EA12432.

Authors:  Yuqi Du; Chen Wang; Guodong Cui; Yiwen Chu; Qian Jia; Yi Wang; Weiming Zhu
Journal:  Front Chem       Date:  2020-05-06       Impact factor: 5.221

7.  Maipomycin A, a Novel Natural Compound With Promising Anti-biofilm Activity Against Gram-Negative Pathogenic Bacteria.

Authors:  Junliang Zhang; Xiaoyan Liang; Shiling Zhang; Zhiman Song; Changyun Wang; Ying Xu
Journal:  Front Microbiol       Date:  2021-01-12       Impact factor: 5.640

8.  NP Analyst: An Open Online Platform for Compound Activity Mapping.

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Journal:  ACS Cent Sci       Date:  2022-01-24       Impact factor: 14.553

Review 9.  Pyridine alkaloids with activity in the central nervous system.

Authors:  Simon X Lin; Maurice A Curtis; Jonathan Sperry
Journal:  Bioorg Med Chem       Date:  2020-10-16       Impact factor: 3.641
  9 in total

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