Literature DB >> 7843403

Curcacycline A--a novel cyclic octapeptide isolated from the latex of Jatropha curcas L.

A J van den Berg1, S F Horsten, J J Kettenes-van den Bosch, B H Kroes, C J Beukelman, B R Leeflang, R P Labadie.   

Abstract

From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional 1H-NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be Gly1-Leu2-Leu3-Gly4-Thr5-Val6-Leu7-Leu8-Gly1+ ++. Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T-cells.

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Year:  1995        PMID： 7843403     DOI： 10.1016/0014-5793(94)01405-p

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  In Vitro Studies of Jatropha curcas L. Latex Spray Formulation for Wound Healing Applications.

Authors:  Kittiya Tinpun; Titpawan Nakpheng; Alwar Ramanujam Padmavathi; Teerapol Srichana
Journal:  Turk J Pharm Sci       Date:  2020-06-22

Review 2.  Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Authors:  Paul G Arnison; Mervyn J Bibb; Gabriele Bierbaum; Albert A Bowers; Tim S Bugni; Grzegorz Bulaj; Julio A Camarero; Dominic J Campopiano; Gregory L Challis; Jon Clardy; Paul D Cotter; David J Craik; Michael Dawson; Elke Dittmann; Stefano Donadio; Pieter C Dorrestein; Karl-Dieter Entian; Michael A Fischbach; John S Garavelli; Ulf Göransson; Christian W Gruber; Daniel H Haft; Thomas K Hemscheidt; Christian Hertweck; Colin Hill; Alexander R Horswill; Marcel Jaspars; Wendy L Kelly; Judith P Klinman; Oscar P Kuipers; A James Link; Wen Liu; Mohamed A Marahiel; Douglas A Mitchell; Gert N Moll; Bradley S Moore; Rolf Müller; Satish K Nair; Ingolf F Nes; Gillian E Norris; Baldomero M Olivera; Hiroyasu Onaka; Mark L Patchett; Joern Piel; Martin J T Reaney; Sylvie Rebuffat; R Paul Ross; Hans-Georg Sahl; Eric W Schmidt; Michael E Selsted; Konstantin Severinov; Ben Shen; Kaarina Sivonen; Leif Smith; Torsten Stein; Roderich D Süssmuth; John R Tagg; Gong-Li Tang; Andrew W Truman; John C Vederas; Christopher T Walsh; Jonathan D Walton; Silke C Wenzel; Joanne M Willey; Wilfred A van der Donk
Journal:  Nat Prod Rep       Date:  2013-01       Impact factor: 13.423

3.  Cytotoxic Activity of Crude Extracts as well as of Pure Components from Jatropha Species, Plants Used Extensively in African Traditional Medicine.

Authors:  Olapeju O Aiyelaagbe; Amao A Hamid; Ernesto Fattorusso; Orazio Taglialatela-Scafati; Heinz C Schröder; Werner E G Müller
Journal:  Evid Based Complement Alternat Med       Date:  2011-06-15       Impact factor: 2.629

4.  Medicinal and ethnoveterinary remedies of hunters in Trinidad.

Authors:  C Lans; T Harper; K Georges; E Bridgewater
Journal:  BMC Complement Altern Med       Date:  2001-11-30       Impact factor: 3.659

5.  Production of cytotoxic compounds in dedifferentiated cells of Jatropha curcas L. (Euphorbiaceae).

Authors:  Isidro Ovando-Medina; Leny P Pérez-Díaz; Sonia Ruiz-González; Miguel Salvador-Figueroa; Marcos E Urbina-Reyes; Lourdes Adriano-Anaya
Journal:  PeerJ       Date:  2016-11-01       Impact factor: 2.984

6.  Insights on the phytochemical profile (cyclopeptides) and biological activities of Calotropis procera latex organic fractions.

Authors:  Thiago Lustosa Jucá; Márcio Viana Ramos; Frederico Bruno Mendes Batista Moreno; Mayara Patrícia Viana de Matos; José Delano Barreto Marinho-Filho; Renato Azevedo Moreira; Ana Cristina de Oliveira Monteiro-Moreira
Journal:  ScientificWorldJournal       Date:  2013-11-18
  6 in total

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